Altered microglial copper homeostasis in a mouse model of Alzheimer's disease.

Journal of Neurochemistry
Zhiqiang ZhengMichael J Petris

Abstract

Alzheimer's disease (AD) is characterized by progressive neurodegeneration associated with the aggregation and deposition of β-amyloid (Aβ(40) and Aβ(42) ) peptide in senile plaques. Recent studies suggest that copper may play an important role in AD pathology. Copper concentrations are elevated in amyloid plaques and copper binds with high affinity to the Aβ peptide and promotes Aβ oligomerization and neurotoxicity. Despite this connection between copper and AD, it is unknown whether the expression of proteins involved in regulating copper homeostasis is altered in this disorder. In this study, we demonstrate that the copper transporting P-type ATPase, ATP7A, is highly expressed in activated microglial cells that are specifically clustered around amyloid plaques in the TgCRND8 mouse model of AD. Using a cultured microglial cell line, ATP7A expression was found to be increased by the pro-inflammatory cytokine interferon-gamma, but not by TNF-α or IL-1β. Interferon-gamma also elicited marked changes in copper homeostasis, including copper-dependent trafficking of ATP7A from the Golgi to cytoplasmic vesicles, increased copper uptake and elevated expression of the CTR1 copper importer. These findings suggest that pro-inflammatory ...Continue Reading

References

Apr 1, 1992·Journal of Neuroscience Research·V BocchiniH Kettenmann
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y YamaguchiJ D Gitlin
Oct 28, 1997·Acta Neuropathologica·A SasakiY Nakazato
Jul 17, 1998·Journal of the Neurological Sciences·M A LovellW R Markesbery
Jan 5, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I BlaskoB Grubeck-Loebenstein
Aug 7, 1999·The Journal of Biological Chemistry·R A ChernyA I Bush
Jun 26, 2001·The Journal of Biological Chemistry·Y YoshiikeA Takashima
Aug 22, 2001·Lancet·A CagninR B Banati
Oct 13, 2001·Dementia and Geriatric Cognitive Disorders·B ReglandC G Gottfries
Sep 7, 2002·The Journal of Biological Chemistry·Christa J MaynardQiao-Xin Li
Nov 19, 2002·The Journal of Biological Chemistry·Cyril C CurtainKevin J Barnham
Dec 12, 2002·Micron : the International Research and Review Journal for Microscopy·J R Harris
Nov 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Amie L PhinneyDavid Westaway
Nov 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thomas A BayerGerd Multhaup
Jul 3, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kevin J BarnhamAshley I Bush
Jul 23, 2004·American Journal of Physiology. Cell Physiology·M GreenoughJ Camakaris
Dec 4, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Xudong HuangAshley I Bush
Jan 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michelle L SchliefJonathan D Gitlin
Jan 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter J CrouchIan A Trounce
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Alon MonsonegoHoward L Weiner
Mar 30, 2006·Journal of Neuroinflammation·Clive BateAlun Williams
Sep 22, 2006·Journal of Alzheimer's Disease : JAD·Muhammad Omar Chohan, Khalid Iqbal
Sep 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michelle L SchliefJonathan D Gitlin
Nov 30, 2006·Journal of Neuroscience Research·Maria Laura GiuffridaEnrico Rizzarelli
Apr 6, 2007·Neuroscience Letters·Shino MagakiWolff M Kirsch
Aug 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jijun DongDavid G Lynn

❮ Previous
Next ❯

Citations

Oct 15, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kan HeYuchun Pan
Feb 9, 2013·The International Journal of Biochemistry & Cell Biology·Natalie K Y WeeStephen J Assinder
Jul 17, 2012·Chemical Reviews·Kasper P Kepp
Feb 8, 2011·Metallomics : Integrated Biometal Science·David J BondaMark A Smith
May 16, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Eric D SmolenskyValerie C Pierre
Feb 15, 2012·Advances in Nutrition·Yanfang WangMichael J Petris
Dec 27, 2013·International Journal of Alzheimer's Disease·Xin Yi ChooAlexandra Grubman
Dec 9, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Mario ArcielloLuisa Rossi
Apr 23, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Om V PatelZhenyu Qin
Jan 26, 2016·Ocular Immunology and Inflammation·Iyer Gomathy NarayananK N Sulochana
Mar 20, 2013·Molecular Aspects of Medicine·Heejeong KimJaekwon Lee
Aug 13, 2013·The International Journal of Neuroscience·Zhiyou CaiLiang-Jun Yan
May 31, 2013·Toxicology and Industrial Health·Shyang LungArezoo Campbell
Dec 22, 2017·International Journal of Environmental Research and Public Health·Stephen C Bondy, Arezoo Campbell
Nov 9, 2017·Frontiers in Molecular Neuroscience·Yong LiHong Jiang
Jul 1, 2011·Nature·Pontus GourdonPoul Nissen
Aug 9, 2013·Metallomics : Integrated Biometal Science·Giselle CerchiaroFernanda Rodrigues Bertuchi
Jul 26, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Kayla N GreenGiridhar Akkaraju
Mar 19, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Rebekka Hueting
Sep 3, 2014·Biology of the Cell·Laurie ErbGary A Weisman
Feb 7, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Heng-Wei HsuMasashi Kitazawa
Oct 5, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Evelyn Tiffany-CastiglioniYongchang Qian
Apr 25, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Asli Ayka, Ahmet Özer Şehirli
Sep 6, 2020·Molecular Neurobiology·Md Tanvir KabirMohamed M Abdel-Daim
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lei JiangZhen Cheng
Oct 22, 2020·International Journal of Molecular Sciences·Hafza Wajeeha EjazMinglin Lang
Dec 10, 2020·Metallomics : Integrated Biometal Science·Ashima BhattacharjeeKaustav Chakraborty
Jan 8, 2021·Brain Research·Baoman LiAlexei Verkhratsky
Nov 22, 2020·The Journal of Biological Chemistry·Peng LeiAshley I Bush
Dec 10, 2020·International Journal of Molecular Sciences·Grażyna GromadzkaAgata Adamczyk
Jun 27, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Fangyu PengRamon Diaz-Arrastia
May 28, 2021·Current Environmental Health Reports·Souvarish Sarkar
Aug 9, 2021·Biochimica Et Biophysica Acta. General Subjects·Bryce BladesSharon La Fontaine
Aug 15, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·May T MaungTeresita Padilla-Benavides
Aug 21, 2020·Journal of the American Chemical Society·Sumin LeeChristopher J Chang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.