Altered mitochondrial trafficking as a novel mechanism of cancer metastasis.

Cancer Reports
Madison Furnish, M Cecilia Caino

Abstract

Mammalian cells must constantly reprogram the distribution of mitochondria in order to meet the local demands for energy, calcium, redox balance, and other mitochondrial functions. Mitochondrial localization inside the cell is a result of a combination of movement along the microtubule tracks plus anchoring to actin filaments. Recent advances show that subcellular distribution of mitochondria can regulate tumor cell growth, proliferation/motility plasticity, metastatic competence, and therapy responses in tumors. In this review, we discuss our current understanding of the mechanisms by which mitochondrial subcellular distribution is regulated in tumor cells. Mitochondrial trafficking is dysregulated in tumors. Accumulation of mitochondria at the leading edge of the cell supports energy expensive processes of focal adhesion dynamics, cell membrane dynamics, migration, and invasion.

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Citations

May 14, 2020·International Journal of Molecular Sciences·Poorva GhoshLi Zhang
Oct 4, 2019·Antioxidants & Redox Signaling·Hsin Yao ChiuReshma Taneja
Jan 8, 2020·International Journal of Molecular Sciences·Louise InjarabianBenoit S Marteyn
Nov 13, 2020·The FEBS Journal·Camila Castillo FerrerGabriel Ichim
Jan 28, 2021·Cancers·Rohit GundamarajuRishya Manikam
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Marte SneeggenCinzia Progida

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