Altered moral decision-making in patients with idiopathic Parkinson's disease

Parkinsonism & Related Disorders
Jan B RosenElke Kalbe

Abstract

Moral decision-making essentially contributes to social conduct. Although patients with Parkinson's disease (PD) show deficits in (non-moral) decision making and related neuropsychological functions, i.e. executive functions, theory of mind (ToM), and empathy, moral decision-making has rarely been examined in PD patients. We examined possible alterations of moral decision-making and associated functions in PD. Twenty non-demented PD patients and 23 age- and education-matched healthy control participants were examined with tests that assess reasoning, executive functions (set-shifting and planning), ToM and empathy, decision-making under risk, and moral intuitions. Moral decision-making was assessed with a close-to-everyday moral dilemma paradigm that opposes socially oriented "altruistic" choices to self-beneficial "egoistic" choices in 20 moral dilemma short stories (10 high and 10 low emotional). Concurrently, electrodermal activity was recorded. PD patients made more egoistic moral decisions than healthy controls. Remarkably, while reasoning, planning and empathy correlated with moral decision-making in the control group, in the PD group neuropsychological functions and dopaminergic medication did not correlate with moral de...Continue Reading

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Citations

May 6, 2016·Frontiers in Behavioral Neuroscience·Jan B RosenElke Kalbe
Aug 29, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·P SantensB R Bloem
Oct 31, 2018·Scientific Reports·Rwei-Ling YuChun-Hsiang Tan
Dec 12, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E A Lyashenko, O V Iakovleva
Jul 18, 2018·Acta neurologica Belgica·Patrick SantensMiet De Letter
Feb 10, 2021·Fortschritte der Neurologie-Psychiatrie·Inga Liepelt-ScarfoneSandra Roeske
Feb 27, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Panpan HuKai Wang
Mar 4, 2021·NPJ Parkinson's Disease·Giorgia PonsiSalvatore Maria Aglioti
Jun 8, 2021·Neuroscience and Biobehavioral Reviews·Janet K X WrightJulie D Henry

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