PMID: 9178808May 16, 1997Paper

Altered mRNA expression of specific molecular species of fucosyl- and sialyl-transferases in human colorectal cancer tissues

International Journal of Cancer. Journal International Du Cancer
H ItoR Kannagi

Abstract

Human colorectal cancers express various cancer-associated carbohydrate determinants such as Lewis Y or sialyl Lewis A, suggesting a considerable alteration in glycosyltransferase activities occurring upon malignant transformation. We investigated the mRNA amounts of fucosyltransferase (Fuc-T) and sialyltransferase (ST) isoenzymes, including Fuc-T III, IV, V, VI and VII and ST-3N, ST-30 and ST-4, in human colorectal cancer tissues by Northern blotting and RT-PCR. Regarding fucosyltransferases, mRNA of Fuc-T III and VI was not significantly altered, and only Fuc-T IV mRNA showed a moderate increase in cancer tissues when compared with adjacent non-malignant colonic epithelia taken from the same patient (273 +/- 96%; p < 0.001). The moderate increase of Fuc-T IV message may be related to an enhanced expression of Lewis Y in colon cancer tissues. In the ST isoenzymes, mRNA for ST-3N remained unchanged, whereas that for ST-4 decreased significantly in cancer tissues, to 32 +/- 29%, (p < 0.005). The most remarkable finding was that the message of ST-30 was prominently increased in cancer tissues compared with non-malignant colorectal mucosa. When further investigated by quantitative RT-PCR assays on a larger series of patients with ...Continue Reading

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Citations

Mar 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·P L BeckR J Xavier
Mar 1, 2017·Biology·Marco TrincheraFabio Dall'Olio
Jul 7, 2017·Pathology Oncology Research : POR·Martín E RabassaMaria V Croce
Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·Rinat EshelIsaac P Witz
Apr 23, 2004·Biological Chemistry·Yanqin ShenRoland Schauer
May 11, 2004·Cancer Science·Reiji KannagiNaoko Kimura
Dec 18, 2013·Proteomics·Maja N ChristiansenNicolle H Packer
May 31, 2002·Japanese Journal of Cancer Research : Gann·Akira SekoKatsuko Yamashita
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Jun 19, 2012·Clinical Epigenetics·Tomislav HorvatGordan Lauc
Sep 12, 2020·International Journal of Molecular Sciences·Michela PucciFabio Dall'Olio
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