Altered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma.

Molecular Medicine
Julieta PaneroIrma Slavutsky

Abstract

In this study, we explored changes in the expression of the telomere maintenance genes, TRF1, TRF2 and TANK1 in patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). Results were correlated with human telomerase reverse transcriptase (hTERT ) expression, telomere length (TL) and clinicopathological characteristics. Bone marrow (BM) samples from 132 patients, 64 with MGUS and 68 with MM, were studied. Real-time quantitative reverse transcription-polymerase chain reaction was used to quantify gene expression. TL was evaluated by terminal restriction fragment length analysis. MGUS patients showed increased TRF1 levels (P = 0.006) and lower expression of TRF2 (P = 0.005) and TANK1 (P = 0.003) compared with MM patients. For hTERT analysis, patients were divided into three groups by use of receiver operating characteristics: low (group I [GI]), intermediate (group II [GII]) and high (group III [GIII]) expression. We observed increasing expression of TRF2 and TANK1 from GI to GIII in MGUS and MM, with differences for both genes in MM (P < 0.01) and for TRF2 in MGUS (P < 0.01). GIII patients with the highest telomerase expression had the shortest TL. In both entities, a positive association ...Continue Reading

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Citations

Jul 1, 2017·PloS One·Patricia Carolina Dos SantosIrma Slavutsky
Sep 10, 2014·International Journal of Cancer. Journal International Du Cancer·Lei WangMichael Schmitt
Feb 8, 2016·American Journal of Hematology·Julieta PaneroRodrigo T Calado
Sep 6, 2012·Journal of Cellular and Molecular Medicine·Rafael Díaz de la GuardiaPaola E Leone
Oct 15, 2014·Molecular Biotechnology·Julieta PaneroIrma Slavutsky
Feb 19, 2021·Cellular and Molecular Life Sciences : CMLS·Semih Can AkincilarVinay Tergaonkar

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