Childhood lead exposure is associated with adverse cognitive, neurobehavioral and motor outcomes, suggesting altered brain structure and function. The purpose of this work was to assess the long-term impact of childhood lead exposure on white matter integrity in young adults. We hypothesized that childhood lead exposure would alter adult white matter architecture via deficits in axonal integrity and myelin organization. Adults (22.9+/-1.5 years, range 20.0-26.1 years) from the Cincinnati Lead Study were recruited to undergo a study employing diffusion tensor imaging (DTI). The anatomic regions of association between water diffusion characteristics in white matter and mean childhood blood lead level were determined for 91 participants (52 female). Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured on an exploratory voxel-wise basis. In adjusted analyses, mean childhood blood lead levels were associated with decreased FA throughout white matter. Regions of the corona radiata demonstrated highly significant lead-associated decreases in FA and AD and increases in MD and RD. The genu, body, and splenium of the corpus callosum demonstrated highly significant lead-assoc...Continue Reading
Lead exposure and the cognitive development of urban preschool children: the Cincinnati Lead Study cohort at age 4 years
Low level lead exposure in the prenatal and early preschool periods: intelligence prior to school entry
Myelin deficits produced by early postnatal exposure to inorganic lead or triethyltin are persistent
Exposure to lead-acetate modulates the developmental expression of myelin genes in the rat frontal lobe
Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI
Chronic lead intoxication affects the myelin membrane status in the central nervous system of adult rats
Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia
Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study
Cognitive functions correlate with white matter architecture in a normal pediatric population: a diffusion tensor MRI study
The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language function
Relations of brain volumes with cognitive function in males 45 years and older with past lead exposure
Longitudinal diffusion tensor magnetic resonance imaging study of radiation-induced white matter damage in a rat model
Differing effects of toxicants (methylmercury, inorganic mercury, lead, amyloid β, and rotenone) on cultured rat cerebrocortical neurons: differential expression of rho proteins associated with neurotoxicity
The translational role of diffusion tensor image analysis in animal models of developmental pathologies.
Low-level environmental lead exposure in childhood and adult intellectual function: a follow-up study.
Lead induces similar gene expression changes in brains of gestationally exposed adult mice and in neurons differentiated from mouse embryonic stem cells
Neuroimaging is a novel tool to understand the impact of environmental chemicals on neurodevelopment
Lead exposure disrupts global DNA methylation in human embryonic stem cells and alters their neuronal differentiation
A brief history of INA and ICOH SCNP: International Neurotoxicology Association and International Congress on Occupational Health Scientific Committee on Neurotoxicology and Psychophysiology
Research Review: Environmental exposures, neurodevelopment, and child mental health - new paradigms for the study of brain and behavioral effects
Atypical prefrontal connectivity in attention-deficit/hyperactivity disorder: pathway to disease or pathological end point?
Developmental lead effects on behavior and brain gene expression in male and female BALB/cAnNTac mice.
Exposure to As, Cd and Pb-mixture impairs myelin and axon development in rat brain, optic nerve and retina
Reduced fractional anisotropy in the visual limbic pathway of young adults witnessing domestic violence in childhood.
Is lead exposure in early life an environmental risk factor for Schizophrenia? Neurobiological connections and testable hypotheses
Altered white matter microstructural integrity revealed by voxel-wise analysis of diffusion tensor imaging in welders with manganese exposure
Early-life lead exposure recapitulates the selective loss of parvalbumin-positive GABAergic interneurons and subcortical dopamine system hyperactivity present in schizophrenia
Early-life metal exposure and schizophrenia: A proof-of-concept study using novel tooth-matrix biomarkers
Variation in an Iron Metabolism Gene Moderates the Association Between Blood Lead Levels and Attention-Deficit/Hyperactivity Disorder in Children
Portable Functional Neuroimaging as an Environmental Epidemiology Tool: A How-To Guide for the Use of fNIRS in Field Studies
The fate and behavior of persistent, bioaccumulative, and toxic (PBT) chemicals: examining lead (Pb) as a PBT metal
Elevated Hair Mercury Levels Are Associated With Neurodevelopmental Deficits in Children Living Near Artisanal and Small-Scale Gold Mining in Peru
Association of Childhood Lead Exposure With MRI Measurements of Structural Brain Integrity in Midlife.
Carbofuran hampers oligodendrocytes development leading to impaired myelination in the hippocampus of rat brain
Reduced regional volumes associated with total psychopathy scores in an adult population with childhood lead exposure
Risk of lead exposure, subcortical brain structure, and cognition in a large cohort of 9- to 10-year-old children.
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