Altered NaCl taste responses precede increased NaCl ingestion during Na(+) deprivation

Physiology & Behavior
K S CurtisR J Contreras

Abstract

It has been suggested that Na(+) deficiency alters the sensitivity of taste receptors, thereby rendering NaCl solutions more palatable or preferred and more likely to be ingested. Increased ingestion of concentrated NaCl solutions by rats during dietary Na(+) deprivation occurs only after approximately 8-10 days. To determine whether changes in gustatory responses mediate the deprivation-induced NaCl ingestion (salt appetite), we evaluated taste responses to a range of NaCl concentrations before, during, and after dietary Na(+) deprivation. Rats were trained to lick rapidly in short-duration (10 s) tests by mixing NaCl solutions in a dilute sucrose solution. This method elicited consistent, interpretable rates of licking, even of normally avoided NaCl concentrations, without the necessity of depriving the rats of water. The licking rate increased after dietary Na(+) deprivation of only 2 days, increased further after 5 days of Na(+) deprivation and, after 10 days, was not different from that after 2 days. These results suggest that a change in the response to NaCl taste, as evidenced by increased rates of licking during short-access tests, occurred after 2 days of dietary Na(+) deprivation. In contrast, a significant increase i...Continue Reading

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Citations

Feb 27, 2004·Physiology & Behavior·Kathleen S CurtisRobert J Contreras
Oct 11, 2003·Appetite·Stephen J SimpsonDavid Raubenheimer
Aug 9, 2006·Behavioral Neuroscience·Kathleen S Curtis, Robert J Contreras
Sep 24, 2004·The British Journal of Nutrition·Martin R YeomansMicah Leshem
Oct 10, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joanne M GarciaRobert J Contreras
Aug 14, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nick A GuagliardoDavid L Hill
Jul 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer M StratfordRobert J Contreras
Jul 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian F SadaccaDonald B Katz
Nov 26, 2013·Progress in Lipid Research·Timothy A Gilbertson, Naim A Khan
Jun 3, 2008·Physiology & Behavior·Michael J MorrisAlan Kim Johnson
Jun 15, 2007·Appetite·Eric G Krause, Randall R Sakai
Nov 19, 2011·Psychophysiology·Mustafa Al'AbsiTiffany Cragin
Sep 26, 2012·Journal of Neuroendocrinology·A S MecawiJ Antunes-Rodrigues
Sep 13, 2006·Appetite·Douglas A FittsJohn E Bassett
Nov 25, 2005·Chemical Senses·David M DietzRobert J Contreras
Nov 17, 2005·Learning & Memory·Eric M Stouffer, Norman M White

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