Altered neural activity and emotions following right middle cerebral artery stroke.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
S ParadisoRobert G Robinson

Abstract

Stroke of the right MCA is common. Such strokes often have consequences for emotional experience, but these can be subtle. In such cases diagnosis is difficult because emotional awareness (limiting reporting of emotional changes) may be affected. The present study sought to clarify the mechanisms of altered emotion experience after right MCA stroke. It was predicted that after right MCA stroke the anterior cingulate cortex (ACC), a brain region concerned with emotional awareness, would show reduced neural activity. Brain activity during presentation of emotional stimuli was measured in 6 patients with stable stroke, and in 12 age- and sex-matched nonlesion comparisons using positron emission tomography and the [(15)O]H(2)O autoradiographic method. MCA stroke was associated with weaker pleasant experience and decreased activity ipsilaterally in the ACC. Other regions involved in emotional processing including thalamus, dorsal and medial prefrontal cortex showed reduced activity ipsilaterally. Dorsal and medial prefrontal cortex, association visual cortex and cerebellum showed reduced activity contralaterally. Experience from unpleasant stimuli was unaltered and was associated with decreased activity only in the left midbrain. Ri...Continue Reading

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Citations

Aug 19, 2014·Brain and Cognition·Luciano Grüdtner BurattoLilian Milnitsky Stein
Jan 23, 2016·Journal of Affective Disorders·Nerissa S P HoTatia M C Lee
Oct 26, 2013·Behavioural Brain Research·Jérôme LindenAndré Ferrara
Jan 9, 2013·Current Opinion in Neurobiology·Justin S Feinstein
Dec 10, 2015·CoDAS·Camila Rosa de OliveiraRochele Paz Fonseca

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