Altered neurocircuitry in the dopamine transporter knockout mouse brain.

PloS One
Xiaowei ZhangRussell E Jacobs

Abstract

The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters. Thus, activity of these transporters has significant consequences for monoamine activity throughout the brain and for a number of neurological and psychiatric disorders. Gene knockout (KO) mice that reduce or eliminate expression of each of these monoamine transporters have provided a wealth of new information about the function of these proteins at molecular, physiological and behavioral levels. In the present work we use the unique properties of magnetic resonance imaging (MRI) to probe the effects of altered dopaminergic dynamics on meso-scale neuronal circuitry and overall brain morphology, since changes at these levels of organization might help to account for some of the extensive pharmacological and behavioral differences observed in dopamine transporter (DAT) KO mice. Despite the smaller size of these animals, voxel-wise statistical comparison of high resolution structural MR images indicated little morphological change as a consequence of DAT KO. Likewise, proton magnetic resonance spectra recorded in the striatum indicated no significant changes in det...Continue Reading

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Citations

May 11, 2012·Developmental Neuroscience·Alex C CarpenterGregg D Stanwood
Mar 8, 2013·PloS One·Joseph J GallagherRussell E Jacobs
Jul 12, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yosefu ArimeIchiro Sora
Sep 24, 2013·Neurobiology of Learning and Memory·Tadashi InuiTsuyoshi Shimura
Jul 8, 2011·Current Opinion in Neurology·Jeff H Duyn, Alan P Koretsky
Nov 13, 2015·Nordic Journal of Psychiatry·Louise K HoeffdingHenrik B Rasmussen
Apr 10, 2016·Behavioural Brain Research·Arthur S C FrançaBruno Lobão-Soares
Feb 7, 2012·NeuroImage·Lindsay S CahillR Mark Henkelman
Jun 9, 2016·Journal of Neurogenetics·Evgeniya V EfimovaTatyana D Sotnikova
Jul 6, 2017·Current Protocols in Molecular Biology·Christopher S MedinaElaine L Bearer
Jan 31, 2018·Frontiers in Integrative Neuroscience·Bruno Oliveira Ferreira SouzaChristian Casanova
Sep 2, 2011·Biological & Pharmaceutical Bulletin·Yosefu ArimeIchiro Sora

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Methods Mentioned

BETA
genetic modifications
transgenic
fluorescence microscopy

Software Mentioned

BrainSuite
QUEST
Java Magnetic Resonance User Interface ( JMRUI )
MRIcro
FastMap
Alignlinear
Matlab
AxioVision
BrainSuite2
MEMRI

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