Altered neuropeptide content and cholinergic enzymatic activity in the inflamed guinea pig jejunum during parasitism

Neuropeptides
J M Palmer, Timothy R Koch

Abstract

We investigated the effects of an enteric infection with the parasitic nematode, Trichinella spiralis, on peptidergic and cholinergic neural pathways of the guinea pig jejunum. The content of the enteric neuropeptides, substance P (SP) and vasoactive intestinal peptide (VIP), and the activities of the key cholinergic enzymes, acetylcholinesterase (AChE) and choline acetyltransferase (ChAT), were measured and compared in extracts of jejunal muscularis externa (ME) obtained from uninfected jejunum and T. spiralis-inflamed jejunum. Significant decreases were detected in both SP immunoreactivity and AChE activity on days 6 and 10 postinfection (PI) in nematode-infected guinea pig jejunum compared to uninfected controls. The maximum changes observed for SP and AChE both occurred on day 10 PI and were evident as decreases of 37% and 48%, respectively, from the mean uninfected control values for SP and AChE. In contrast, VIP immunoreactivity and ChAT activity showed no significant changes during the enteric phase of T. spiralis infection. Nematode-evoked histopathological changes in jejunal tissues from infected animals were associated with significant increases in myeloperoxidase (MPO) activity, an index of inflammation intensity, wh...Continue Reading

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Citations

Feb 17, 2005·Digestive Diseases and Sciences·Timothy R KochEmmanuel C Opara
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Sep 19, 2006·British Journal of Pharmacology·C L Hirota, D M McKay
Dec 17, 2009·British Journal of Pharmacology·Inge DepoortereJan Tack
Aug 26, 1998·Experimental Neurology·K A DavisM G Blennerhassett
Jun 7, 2008·Autonomic Neuroscience : Basic & Clinical·Mariona AulíEster Fernández
Apr 17, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christina L GreenDerek M McKay
Jun 28, 2001·The Journal of Parasitology·J M Palmer, B Greenwood-Van Meerveld
Dec 17, 2008·Reproduction in Domestic Animals = Zuchthygiene·M A M Taverne, G C van der Weijden
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aiping ZhaoTerez Shea-Donohue

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