Altered nitric oxide production in the premature gut may increase susceptibility to intestinal damage in necrotizing enterocolitis

Journal of Pediatric Surgery
M Di Lorenzo, A Krantis

Abstract

Nitric oxide (NO) mediates enteric smooth muscle relaxation and mucosal protection. The authors have identified an ontogenically determined pattern of enteric NO neural maturation that may render the distal gut of premature piglets susceptible to injury. NO synthase (cNOS and iNOS) activities were measured in the developing piglet gut wall and compared with gut from an intraluminal model of necrotizing enterocolitis (NEC) at different times. In premature animals, iNOS activity was significantly higher 3 hours after NEC induction compared with similarly treated 3-day-old piglets. INOS levels continued to rise 6 hours after NEC induction in prematures. Premature animals (labor induced by prostaglandins) failed to show such a rise in iNOS. In 3 day olds, iNOS levels increased significantly 16 hours after injury compared with the 3-hour group. iNOS production increases in premature piglets with NEC compared with full-term NEC animals and continues to rise in the presence of intestinal damage regardless of developmental status. Maternal administration of prostaglandins attenuates this rise in iNOS activity. Elevated NO production in premature gut may contribute to increased susceptibility to damage in NEC.

Citations

Jan 30, 2004·Journal of Gastroenterology and Hepatology·Kiarash RiaziAhmad Reza Dehpour
Apr 15, 2008·World Journal of Gastroenterology : WJG·Kareena-L SchnablMichael-T Clandinin
Aug 9, 2005·Seminars in Pediatric Surgery·Jeffrey S UppermanHenri R Ford
Apr 5, 2005·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sanjay Patole
Jul 22, 2008·Nursing Research·Katherine E Gregory
Mar 23, 2013·African Journal of Paediatric Surgery : AJPS·Muazez CevikDidem Daskin Embleton
Mar 11, 2009·Journal of Pediatric Gastroenterology and Nutrition·Peter J GiannoneKristina M Reber
Aug 21, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Brenna M FlanneryJames J Pestka
May 19, 2007·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·P J GiannoneK M Reber
Dec 2, 2006·Experimental Biology and Medicine·Per T Sangild

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