Altered nuclear envelope structure and proteasome function of micronuclei

Experimental Cell Research
Kendra K MaassAurélie Ernst

Abstract

Micronuclei are extra-nuclear bodies containing whole chromosomes that were not incorporated into the nucleus after cell division or damaged chromosome fragments. Even though the link between micronuclei and DNA damage is described for a long time, little is known about the functional organization of micronuclei and their contribution to tumorigenesis. We showed fusions between micronuclear membranes and lysosomes by electron microscopy and linked lysosome function to DNA damage levels in micronuclei. In addition, micronuclei drastically differ from primary nuclei in nuclear envelope composition, with a significant increase in the relative amount of nuclear envelope proteins LBR and emerin and a decrease in nuclear pore proteins. Strikingly, micronuclei lack active proteasomes, as the processing subunits and other factors of the ubiquitin proteasome system. Moreover, micronuclear chromatin shows a higher degree of compaction as compared to primary nuclei. The specific aberrations identified in micronuclei and the potential functional consequences of these defects may contribute to the role of micronuclei in catastrophic genomic rearrangements.

Citations

Feb 8, 2020·The Journal of Cell Biology·Brandt WareckiWilliam Sullivan
Sep 20, 2020·International Journal of Cancer. Journal International Du Cancer·Xihan GuoXu Wang
May 16, 2019·Genes·Christine J YeHenry H Heng
Jul 19, 2020·Archives of Toxicology·Hauke ReimannHenning Hintzsche
Jul 18, 2020·International Journal of Molecular Sciences·Guadalupe Elizabeth Jimenez-GutierrezBulmaro Cisneros
Feb 21, 2021·Seminars in Cell & Developmental Biology·F PellestorV Gatinois
May 2, 2021·International Journal of Cancer. Journal International Du Cancer·Thorsten Kolb, Aurélie Ernst
Aug 8, 2021·International Journal of Molecular Sciences·Alessio MalacridaMariarosaria Miloso
Jan 30, 2021·Molecular Syndromology·Martin Poot

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