Altered nuclei-specific thalamic functional connectivity patterns in multiple sclerosis and their associations with fatigue and cognition

Multiple Sclerosis : Clinical and Laboratory Research
Fuchun LinMichael G Dwyer

Abstract

The thalamus, affected early in multiple sclerosis (MS), is a heterogeneous composition of functionally distinct nuclei and is associated with fatigue, cognition, and other outcomes. However, most previous functional imaging studies considered the thalamus only as a whole. To investigate MS-related abnormalities in nuclei-specific thalamic functional connectivity (FC) and their associations with fatigue and cognitive outcomes. Resting-state functional magnetic resonance imaging (fMRI) was analyzed in 64 MS patients and 26 healthy controls (HC). Whole-brain FC maps for four thalamic subregions seeds were computed for each subject. FC maps were compared between groups, and group by FC interaction effects were assessed for fatigue and cognitive measures. MS patients had decreased FC between the left medial thalamic nuclei and left angular gyrus and reduced FC between the left posterior thalamic nuclei and left supramarginal gyrus, as well as decreased right medial thalamic nuclei connectivity with bilateral caudate/thalamus and left cerebellar areas (p < 0.05 corrected). MS patients had increased FC between the left anterior thalamic nuclei and anterior cingulate cortex bilaterally. There were significant relationships between con...Continue Reading

References

Aug 31, 1992·Neuroscience Letters·H C ChandlerR L Reep
Sep 1, 1992·Neurology·S M OppenheimerV C Hachinski
Jun 1, 1991·Brain Research Bulletin·L J Freedman, M D Cassell
Feb 20, 2007·Journal of Neural Transmission·R Alelú-Paz, J M Giménez-Amaya
Nov 7, 2008·Multiple Sclerosis : Clinical and Laboratory Research·J SepulcreP Villoslada
Jun 16, 2010·Psychological Science·C Nathan DewallNaomi I Eisenberger
Jul 31, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Massimiliano CalabresePaolo Gallo
Aug 16, 2011·NeuroImage·René A ColoradoPonnada A Narayana
Feb 7, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Anthony FaivreBertrand Audoin
Sep 27, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Anne-Marie DogonowskiKristoffer H Madsen
Jan 18, 2013·Multiple Sclerosis : Clinical and Laboratory Research·M BozzaliM Cercignani
Jul 6, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Álvaro J Cruz-GómezCristina Forn
Jul 23, 2013·Brain : a Journal of Neurology·Robert Leech, David J Sharp
Dec 12, 2013·Multiple Sclerosis : Clinical and Laboratory Research·B BasileM Bozzali
Dec 24, 2013·Brain and Behavior·Maria EngströmThomas Karlsson
Aug 26, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Matteo PardiniLuca Roccatagliata
Feb 1, 2015·European Journal of Radiology·Yaou LiuKuncheng Li
Apr 18, 2015·Frontiers in Neurology·Nancy D ChiaravallotiJohn DeLuca
Feb 28, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Ralph Hb BenedictBianca Weinstock-Guttman
Jul 4, 2016·Current Opinion in Neurobiology·Jutta Peterburs, John E Desmond
Jun 29, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Milagros Hidalgo de la CruzMaria Assunta Rocca

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Citations

Apr 21, 2019·Expert Review of Neurotherapeutics·Dejan JakimovskiRobert Zivadinov
Apr 21, 2020·Expert Review of Neurotherapeutics·Eleonora TavazziNiels Bergsland
Apr 24, 2020·Molecular Psychiatry·Milagros Hidalgo de la CruzMaria A Rocca
Oct 13, 2020·Journal of Magnetic Resonance Imaging : JMRI·Niels BergslandRobert Zivadinov
Jan 14, 2021·Nature Reviews. Neurology·Declan T ChardUNKNOWN MAGNIMS Study Group
Feb 23, 2021·Frontiers in Neurology·Moein Amin, Daniel Ontaneda
Jul 23, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C GiannìP Pantano
Jul 24, 2021·Cerebral Cortex·Gianpaolo Antonio BasileAlberto Cacciola

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