Altered oligosaccharide structures reduce colitis induction in mice defective in β-1,4-galactosyltransferase

Gastroenterology
Shinichiro ShinzakiEiji Miyoshi

Abstract

Oligosaccharide modifications induce various functional changes in immune cells. The galactose-deficient fraction of fucosylated IgG oligosaccharides is increased, whereas that of β-1,4-galactosyltransferase I (B4GalTI) is reduced, in patients with Crohn's disease. We investigated the role of oligosaccharide modification in the pathophysiology of colitis using B4galt1-deficient mice. Colitis severity was compared between B4galt1(+/-) and B4galt1(+/+) mice. B cells isolated from B4galt1(+/-) and B4galt1(+/+) mice were adoptively transferred to recombination activating gene 2(-/-) mice, in which colitis was induced by administration of CD4(+)CD62L(+) T cells. Cell-surface glycan profiles were determined by lectin microarray analysis. Cytokine production was determined in a coculture of various types of cells isolated from either B4galt1(+/-) or B4galt1(+/+) mice. Colitis induction by dextran sodium sulfate or trinitrobenzene sulfonic acid was significantly reduced in B4galt1(+/-) mice, which had galactose deficiency in IgG oligosaccharides (similar to patients with Crohn's disease) compared with B4galt1(+/+) mice. Amelioration of colitis was associated with increased production of interleukin-10 by macrophages in B4galt1(+/-) mic...Continue Reading

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Citations

Jan 3, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Takeshi TomodaKazuhide Yamamoto
Jan 13, 2015·Molecular Medicine Reports·Yoshihiro KamadaEiji Miyoshi
Dec 26, 2015·Journal of Gastroenterology·Motohiro Nonaka
Sep 1, 2015·Journal of Gastroenterology·Eri ShiraishiTetsuo Takehara
Apr 5, 2016·Journal of Molecular Biology·Pamela Stanley
Oct 30, 2012·BMB Reports·Eiji MiyoshiYoshihiro Kamada
Feb 28, 2013·Chemical Society Reviews·Jun HirabayashiHiroaki Tateno
Mar 25, 2017·Journal of Biochemistry·Shinichiro ShinzakiEiji Miyoshi
May 20, 2020·Journal of Gastroenterology and Hepatology·Shuko IwataniTetsuo Takehara
Mar 18, 2021·Autoimmunity Reviews·Xing ZhouWeici Zhang

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