Altered orbitofrontal sulcogyral patterns in gambling disorder: a multicenter study

Translational Psychiatry
Yansong LiGuillaume Sescousse

Abstract

Gambling disorder is a serious psychiatric condition characterized by decision-making and reward processing impairments that are associated with dysfunctional brain activity in the orbitofrontal cortex (OFC). However, it remains unclear whether OFC functional abnormalities in gambling disorder are accompanied by structural abnormalities. We addressed this question by examining the organization of sulci and gyri in the OFC. This organization is in place very early and stable across life, such that OFC sulcogyral patterns (classified into Types I, II, and III) can be regarded as potential pre-morbid markers of pathological conditions. We gathered structural brain data from nine existing studies, reaching a total of 165 individuals with gambling disorder and 159 healthy controls. Our results, supported by both frequentist and Bayesian statistics, show that the distribution of OFC sulcogyral patterns is skewed in individuals with gambling disorder, with an increased prevalence of Type II pattern compared with healthy controls. Examination of gambling severity did not reveal any significant relationship between OFC sulcogyral patterns and disease severity. Altogether, our results provide evidence for a skewed distribution of OFC sul...Continue Reading

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Citations

Oct 10, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eve H Limbrick-OldfieldLuke Clark
Aug 10, 2019·Current Behavioral Neuroscience Reports·Damien BreversJoël Billieux
Feb 8, 2020·Clinical EEG and Neuroscience·Motoaki NakamuraMartha E Shenton
Dec 18, 2020·Frontiers in Psychiatry·Nestor SzermanCelso Arango

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