Altered osmotic thresholds for arginine vasopressin secretion and thirst during superovulation and in the ovarian hyperstimulation syndrome (OHSS): relevance to the pathophysiology of OHSS

Fertility and Sterility
I O EvbuomwanA P Murdoch

Abstract

To test the hypothesis that decreases in and maintenance of a new steady state in plasma osmolality and sodium level in ovarian hyperstimulation syndrome (OHSS) are due to altered osmoregulation of arginine vasopressin secretion and thirst. Prospective study. IVF-ET program in a university-based assisted reproductive treatment center. Eight women undergoing superovulation for IVF-ET and five women with normal menstrual cycles. Two-hour infusion of 5% saline on day 3 or 4 after hCG administration in patients undergoing IVF or in the early luteal phase in controls. A 5% saline infusion test was done on day 10 after hCG administration in one patient with OHSS and one patient without OHSS, both of whom were undergoing IVF. Comparison of changes in thresholds for thirst and plasma vasopressin to plasma osmolality. Changes in urine osmolality, plasma electrolytes, hemoglobin level, and hematocrit were assessed at baseline and during infusion of 5% saline. The sensitivity of the changes in arginine vasopressin secretion and thirst after 5% saline infusion was similar in IVF patients on day 3 or 4 after hCG and controls. However, the osmotic threshold was significantly lower by 6 mOsm/kg in IVF patients. By day 10 after hCG, the lower ...Continue Reading

References

Jul 1, 1976·Kidney International·G L RobertsonS Athar
Nov 1, 1988·Clinical Endocrinology·P H Baylis, C J Thompson
Jan 1, 1985·Clinical Endocrinology·B A SpruceM J Watson
Jan 1, 1982·Journal of Immunoassay·P Rooke, P H Baylis
Sep 1, 1995·British Journal of Anaesthesia·D H BeckG B Smith
Jul 13, 1999·Human Reproduction·I O EvbuomwanA P Murdoch
Apr 28, 2000·Fertility and Sterility·J G Whelan, N F Vlahos

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Citations

Mar 15, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·A Le GouezF-J Mercier
Sep 21, 2013·Human Fertility : Journal of the British Fertility Society·Isaac Evbuomwan
Jan 19, 2018·Perioperative Medicine·Fintan HughesHugh Montgomery

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