Altered parahippocampal gyrus activation and its connectivity with resting-state network areas in schizophrenia: An EEG study.

Schizophrenia Research
Sunaina SoniRatna Sharma

Abstract

Synchronized and coherent activity in resting-networks during normal brain functioning could be altered in disconnection syndrome like schizophrenia. Study of neural oscillations as assessed by EEG appears to be a promising proposition to understand the pathophysiology of schizophrenia in patients and their first-degree relatives, where disturbances in neural oscillations point towards genetic predisposition. Therefore, present study aims at establishing EEG based biomarkers for early detection and management strategies. Thirty-two patients with schizophrenia, 28 first-degree relatives and 31 healthy controls (HC) participated in the study. Resting brain activity was recorded using 128-channel electroencephalography. After pre-processing and independent component analysis (ICA), an equivalent current dipole was estimated for each IC. Total of 1551 independent and localizable EEG components across all groups were used in subsequent analysis. Power spectral density and source coherence between IC clusters were computed. Patients and first-degree relatives displayed significantly higher power spectral density (PSD) than HC for all frequency bands in left parahippocampal gyrus (PHG) (-7, -26, 8; BA 27). Another region within left d...Continue Reading

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Citations

Feb 14, 2021·Neuroscience and Biobehavioral Reviews·Bianca Bianciardi, Peter J Uhlhaas

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