Altered peripheral myelination in mice lacking GABAB receptors

Molecular and Cellular Neurosciences
Valerio MagnaghiBernhard Bettler

Abstract

Emerging evidence implicates gamma-aminobutyric acid type B (GABA(B)) receptors in peripheral nervous system (PNS) functions. In order to elucidate which biochemical, morphological and functional parameters of peripheral nerve fibers depend on GABA(B) receptors we studied GABA(B1)-deficient mice, which are devoid of functional GABA(B) receptors. Here, we show that GABA(B1)-deficient mice exhibit morphological and molecular changes in peripheral myelin, including an increase in the number of irregular fibers and increases in the expression levels of the myelin proteins PMP22 and P0. Moreover, the number of small myelinated fibers and small neurons of the lumbar dorsal root ganglia is higher in GABA(B1)-deficient mice than in wild-type littermates. We further show that GABA(B1)-deficient mice exhibit gait alterations and reduced allodynia. In summary, our findings implicate GABA(B) receptors in the PNS myelination process and raise the possibility that PNS alterations contribute to the sensory phenotypes of GABA(B1)-deficient mice.

References

Nov 3, 1978·Brain Research·D A Brown, S Marsh
Apr 23, 1990·Brain Research·A J Todd, V Lochhead
May 1, 1986·British Journal of Pharmacology·A C Dolphin, R H Scott
Jun 1, 1989·Clinical Neuropharmacology·G H Fromm
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·J Sawynok
Feb 1, 1984·British Journal of Pharmacology·M DésarmenienR Schlichter
Mar 23, 1984·European Journal of Pharmacology·R W OlsenJ K Wamsley
Jun 15, 1995·Journal of Neuroscience Research·I M ParhadA W Clark
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·N G Bowery
May 1, 1996·Neuron·M SeredaK A Nave
Dec 1, 1996·Trends in Pharmacological Sciences·M Malcangio, N G Bowery
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·M Diversé-PierluissiK Dunlap
Jul 18, 1997·Journal of Neuroscience Methods·K KlapdorF J Van der Staay
Apr 16, 1998·Histochemistry and Cell Biology·E DráberováP Dráber
Jul 31, 1998·Trends in Neurosciences·C O Hanemann, H W Müller
Jan 6, 1999·Biochemical and Biophysical Research Communications·S IsomotoK Taniyama
Mar 17, 1999·The Journal of Comparative Neurology·M Margeta-MitrovicA I Basbaum
Aug 17, 1999·Cephalalgia : an International Journal of Headache·R Hering-Hanit
Dec 23, 1999·Pharmacology & Toxicology·M SabetkasaiM R Zarrindast
Jul 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·P LorenteG Vassort
Sep 21, 2000·The European Journal of Neuroscience·S TowersN G Bowery
Nov 21, 2000·Current Opinion in Neurobiology·J M Bronstein
Nov 22, 2000·Molecular and Cellular Neurosciences·A CouveM N Pangalos
Jun 21, 2001·Molecular and Cellular Neurosciences·H M ProsserM N Pangalos
Jan 23, 2002·The Clinical Journal of Pain·Søren H Sindrup, Troels S Jensen
May 1, 2002·Anesthesiology·T Philip MalanFrank Porreca
Sep 24, 2002·Brain : a Journal of Neurology·A Robaglia-SchluppM Fontés
Oct 19, 2002·Science·R Douglas Fields, Beth Stevens-Graham
Jan 18, 2003·Cellular and Molecular Life Sciences : CMLS·R H Quarles

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Citations

Jan 5, 2012·Journal of Molecular Neuroscience : MN·Alessandro FaroniValerio Magnaghi
Jun 1, 2012·Journal of Molecular Neuroscience : MN·Alessandro FaroniValerio Magnaghi
Oct 8, 2009·Human Molecular Genetics·Perciliz L Tan, Nicholas Katsanis
Feb 18, 2014·Neurochemical Research·Kenneth E McCarson, S J Enna
Feb 7, 2016·Brain, Behavior, and Immunity·Tadhg CrowleyOlivia F O'Leary
Jul 31, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Yueh-Feng SungShiou-Ping Lin
Nov 15, 2011·Neurotoxicology·Alessandra GilardiniDaniel A Kirschner
Jan 17, 2009·Brain Research Reviews·Cyril GoudetJean-Philippe Pin
May 28, 2011·Journal of Neuroscience Research·Alessandro FaroniValerio Magnaghi
Apr 22, 2011·Journal of Biomedical Materials Research. Part a·Valerio MagnaghiPaolo Ferruti
Jun 7, 2014·Journal of Neuroscience Research·A FaroniA Verkhratsky
Dec 3, 2014·Advanced Drug Delivery Reviews·Alessandro FaroniAdam J Reid
Aug 29, 2014·BioMed Research International·Valerio MagnaghiGiorgio Pajardi
Apr 11, 2009·Journal de la Société de biologie·Marc Landry, Frédéric Nagy
May 19, 2012·Nature Reviews. Neuroscience·Martin Gassmann, Bernhard Bettler
Jun 5, 2019·Proceedings of the National Academy of Sciences of the United States of America·Injae HwangJae Bum Kim
Nov 14, 2019·Development·Robert FledrichRuth M Stassart
Jan 7, 2020·Diabetes & Metabolism Journal·Injae Hwang, Jae Bum Kim
Apr 14, 2020·Developmental Neurobiology·Emma R WilsonM Laura Feltri
Jun 28, 2018·Molecular Neurobiology·Alessandro FaroniValerio Magnaghi
Sep 26, 2020·Frontiers in Cellular Neuroscience·Mari Paz Serrano-RegalMaría Victoria Sánchez-Gómez
Oct 5, 2020·The European Journal of Neuroscience·Valerio MagnaghiAlessandro Faroni
Jul 22, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Suzan BoutaryLiliane Massaad-Massade

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