Altered phenotype of the vestibular organ in GLAST-1 null mice.

Journal of the Association for Research in Otolaryngology : JARO
Sebastian P SchravenMarlies Knipper

Abstract

Various studies point to a crucial role of the high-affinity sodium-coupled glutamate aspartate transporter GLAST-1 for modulation of excitatory transmission as shown in the retina and the CNS. While 2-4-month-old GLAST-1 null mice did not show any functional vestibular abnormality, we observed profound circling behavior in older (7 months) animals lacking GLAST-1. An unchanged total number of otoferlin-positive vestibular hair cells (VHCs), similar ribbon numbers in VHCs, and an unchanged VGLUT3 expression in type II VHCs were detected in GLAST-1 null compared to wild-type mice. A partial loss of supporting cells and an apparent decline of a voltage-gated channel potassium subunit (KCNQ4) was observed in postsynaptic calyceal afferents contacting type I VHCs, together with a reduction of neurofilament- (NF200-) and vesicular glutamate transporter 1- (VGLUT1-) positive calyces in GLAST-1 null mice. Taken together, GLAST-1 deletion appeared to preferentially affect the maintenance of a normal postsynaptic/neuronal phenotype, evident only with increasing age.

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Citations

Oct 12, 2014·Human Molecular Genetics·Teresa RequenaJosé A Lopez-Escamez
Aug 2, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Carrie M NielsonYi-Hsiang Hsu
Jul 12, 2019·Frontiers in Aging Neuroscience·Guoqiang WanGabriel Corfas
Mar 20, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yi-Hsiang HsuDavid Karasik

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