PMID: 1252088Feb 1, 1976Paper

Altered phospholipid metabolism in a temperature-sensitive mutant of a thermophilic bacillus

Archives of Microbiology
L L Kostiw, K A Souza

Abstract

The phospholipid metabolism of a temperature-sensitive mutant of a thermophilic bacillus was studied after the shift from a permissive (58 degrees C) to a restrictive (65 degrees C) growth temperature. During the short period of growth of the mutant at 65 degrees C, the proportions of cardiolipin and its 3-acyl derivative (lyso-cardiolipin) increased, and the proportions of phosphatidylglycerol and phosphatidylethanolamine decreased on cell dry weight basis. In 32P incorporation and turnover experiments, phosphatidylglycerol showed the most rapid uptake and loss of the label. Turnover of cardiolipin, limited to a short period, ceased 18 min after the shift, as did the turnover of phosphatidylethanolamine. In the absence of net phospholipid synthesis, there was a quantitative conversion of phosphatidylglycerol to cardiolipin and an increase in the proportion of lyso-cardiolipin. Chloramphenicol, added to the medium at the time of the shift, reduced the rate of phospholipid synthesis, prevented the increase in the proportions of cardiolipin and lyso-cardiolipin, and slowed the decrease in the proportions of the other two phospholipids. The results indicated a defect in the regulatory mechanism(s) of phospholipid metabolism in the...Continue Reading

References

Mar 24, 1975·Biochimica Et Biophysica Acta·A AudetP Proulx
Mar 28, 1974·Biochimica Et Biophysica Acta·R ColeP Proulx
Aug 1, 1974·Journal of General Microbiology·D E MinnikinJ Baddiley
Feb 14, 1972·Biochimica Et Biophysica Acta·J E Cronan, P R Vagelos
Nov 1, 1973·Journal of Bacteriology·J F SteenbakkersP G de Haan
Dec 1, 1972·Journal of Bacteriology·J A Op den KampL L van Deenen
Dec 1, 1972·Journal of Bacteriology·P D CrowfootS J Wakil
Jul 1, 1972·Journal of Bacteriology·L L KostiwB J Tyson
Oct 10, 1968·Biochemical and Biophysical Research Communications·Y SokawaY Kaziro
Jan 21, 1969·Biochimica Et Biophysica Acta·H Okuyama, S Nojima
May 1, 1969·Journal of Bacteriology·U HenningG Deppe
Dec 2, 1965·Biochimica Et Biophysica Acta·U M Houtsmuller, L L van Deenen
Jul 1, 1969·Journal of Bacteriology·J A den KampL L van Deenen
Jan 21, 1969·Biochimica Et Biophysica Acta·Y Ono, S Nojima
Jul 1, 1959·Biochimica Et Biophysica Acta·F SNYDER, N STEPHENS
Jan 29, 1962·Biochimica Et Biophysica Acta·O RENKONEN
Dec 31, 1949·Nature·C S HANES, F A ISHERWOOD
Dec 1, 1970·The Journal of Membrane Biology·U HopferW J Lennarz

❮ Previous
Next ❯

Citations

Aug 1, 1991·Journal of Bacteriology·L Wu, N E Welker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.