Altered prefrontal cortical MARCKS and PPP1R9A mRNA expression in schizophrenia and bipolar disorder

Schizophrenia Research
Glenn T KonopaskeFrancine M Benes

Abstract

We previously observed dendritic spine loss in the dorsolateral prefrontal cortex (DLPFC) from schizophrenia and bipolar disorder subjects. In the current study, we sought to determine if the mRNA expression of genes known to regulate the actin cytoskeleton and spines correlated with spine loss. Five candidate genes were identified using previously obtained microarray data from the DLPFC from schizophrenia and control subjects. The relative mRNA expression of the genes linked to dendritic spine growth and function, i.e. IGF1R, MARCKS, PPP1R9A, PTPRF, and ARHGEF2, was assessed using quantitative real-time PCR (qRT-PCR) in the DLPFC from a second cohort including schizophrenia, bipolar disorder, and control subjects. Functional pathway analysis was conducted to determine which actin cytoskeleton-regulatory pathways the genes of interest interact with. MARCKS mRNA expression was increased in both schizophrenia and bipolar disorder subjects. PPP1R9A mRNA expression was increased in bipolar disorder subjects. For IGF1R, mRNA expression did not differ significantly among groups; however, it did show a significant, negative correlation with dendrite length. MARCKS and PPP1R9A mRNA expression did not correlate with spine loss, but they...Continue Reading

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Citations

Feb 4, 2016·Neural Plasticity·Harry Pantazopoulos, Sabina Berretta
Apr 12, 2016·Journal of Neurochemistry·Kai-C SonntagTsung-Ung W Woo
Oct 12, 2017·The International Journal of Neuropsychopharmacology·Samira S ValvassoriJoão Quevedo
Jul 2, 2016·Scientific Reports·Mohammed UddinStephen W Scherer
Mar 6, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Gabriele CheliniSabina Berretta
Oct 28, 2019·Frontiers in Genetics·Maureen A MalloyLaurie K Svoboda

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