Altered primate glomerular development due to in utero urinary tract obstruction

Kidney International
D G MatsellA F Tarantal

Abstract

In utero urinary tract obstruction is an important cause of newborn and childhood renal failure. Ureteric obstruction during active nephrogenesis results in cystic renal dysplasia; the earlier and longer the obstruction the more severe the histopathological changes of dysplasia. We have reported on a non-human primate model of non-surgical in utero fetal ureteric obstruction that accurately reflects the human equivalent of obstructive renal dysplasia. A striking feature of this model is the effect of obstruction on normal glomerular development and podocyte survival. To study the effect of urinary obstruction on glomerular development, kidneys were studied from fetuses undergoing unilateral ureteric obstruction by ultrasound guided injection of alginate beads as early as 75 days gestation (term gestation = 165 +/- 10 days). These kidneys displayed all the features of human obstructive cystic dysplasia, had reduced weights, and significant deficiencies in terminal ureteric duct branching. A combination of histochemistry, histomorphometry, and immunocytochemistry was used to demonstrate deficient cortical ureteric duct development and branching, reduced glomerular number, and altered glomerular basement membrane formation with in...Continue Reading

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Citations

Oct 22, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Robert L ChevalierSusan C Kiley
Apr 12, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Alice F TarantalSimon R Cherry
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Mar 13, 2003·Kidney International·Adrian S Woolf
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Jul 8, 2009·Pediatric Research·Alyssa C LeapleyAlice F Tarantal
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May 26, 2009·American Journal of Primatology·Fidiniaina RaharisonJean Sautet
Sep 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Cynthia A BatchelderAlice F Tarantal
Sep 8, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Cynthia A BatchelderAlice F Tarantal
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Oct 11, 2003·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J Schanstra, J L Bascands

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