Jul 27, 2010

Altered production of brain-derived neurotrophic factor by peripheral blood immune cells in multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
Satoshi YoshimuraJun-ichi Kira

Abstract

Within multiple sclerosis lesions, brain-derived neurotrophic factor is detected in neurons and immunocytes. To clarify brain-derived neurotrophic factor production by peripheral blood immunocytes and its relationship with clinical parameters in multiple sclerosis. Serum brain-derived neurotrophic factor levels were measured by conventional enzyme-linked immunosorbent assay while brain-derived neurotrophic factor production by immunocytes was determined by an in situ enzyme-linked immunosorbent assay in 74 multiple sclerosis patients, 32 healthy controls, and 86 patients with other neurological diseases. The tyrosine kinase receptor TrkB expression level in peripheral blood mononuclear cells was measured by real-time polymerase chain reaction. Multiple sclerosis patients showed significantly higher serum brain-derived neurotrophic factor levels than healthy controls and patients with other neurological diseases. Multiple sclerosis patients with high brain-derived neurotrophic factor levels were younger, and showed fewer relapse numbers than those with low brain-derived neurotrophic factor levels. Brain-derived neurotrophic factor production by T cells increased with age in healthy controls, but not in multiple sclerosis patient...Continue Reading

Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Neurotrophic Tyrosine Kinase Receptor Type 2
T-Lymphocyte
Peripheral Blood
Peripheral Blood Mononuclear Cells (Lab Test)
Recombinant Interferon Beta
Neurons
Recombinant Brain-Derived Growth Factors
Brain-Derived Neurotrophic Factor Measurement
NTRK2 gene

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