Altered production of brain-derived neurotrophic factor by peripheral blood immune cells in multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
Satoshi YoshimuraJun-ichi Kira

Abstract

Within multiple sclerosis lesions, brain-derived neurotrophic factor is detected in neurons and immunocytes. To clarify brain-derived neurotrophic factor production by peripheral blood immunocytes and its relationship with clinical parameters in multiple sclerosis. Serum brain-derived neurotrophic factor levels were measured by conventional enzyme-linked immunosorbent assay while brain-derived neurotrophic factor production by immunocytes was determined by an in situ enzyme-linked immunosorbent assay in 74 multiple sclerosis patients, 32 healthy controls, and 86 patients with other neurological diseases. The tyrosine kinase receptor TrkB expression level in peripheral blood mononuclear cells was measured by real-time polymerase chain reaction. Multiple sclerosis patients showed significantly higher serum brain-derived neurotrophic factor levels than healthy controls and patients with other neurological diseases. Multiple sclerosis patients with high brain-derived neurotrophic factor levels were younger, and showed fewer relapse numbers than those with low brain-derived neurotrophic factor levels. Brain-derived neurotrophic factor production by T cells increased with age in healthy controls, but not in multiple sclerosis patient...Continue Reading

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Citations

Mar 20, 2015·Multiple Sclerosis and Related Disorders·George Anderson, Moses Rodriguez
Mar 20, 2015·Multiple Sclerosis and Related Disorders·Alfredo DamascenoLeonilda Maria Barbosa dos Santos
Nov 23, 2019·Journal of Speech, Language, and Hearing Research : JSLHR·Sigfus KristinssonJulius Fridriksson
Jun 4, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A A SemkinaM B Abadzhyan
Oct 26, 2021·Cellular and Molecular Neurobiology·Hussein BaharlooiMaryam Azimi

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