PMID: 8587443Jan 1, 1995Paper

Altered production of endothelin-1 in the hypertrophied rat heart

Journal of Cardiovascular Pharmacology
S SakaiK Goto

Abstract

Although endothelin-1 (ET-1) has been shown to have potent hypertrophic effects in cultured cardiac myocytes, there is no evidence that the production of ET-1 is altered in the hypertrophied heart in vivo. We investigated mRNA and peptide levels of ET-1 in the rat heart hypertrophied due to pressure or volume overload. One week after surgery of abdominal aortic banding (AB) or aortic valve regurgitation (AR; the aortic valve was destroyed by a polyethylene catheter), the rats were sacrificed. Control sham-operated rats were also studied (AB-sham and AR-sham). The left ventricular (LV) weight to body weight ratio was significantly higher in AB rats than in AB-sham rats. It was also significantly higher in AR rats than in AR-sham rats. Therefore, AB rats and AR rats developed LV hypertrophy due to pressure and volume overload, respectively. The expression of ET-1 mRNA in the LV was markedly higher in AB rats than in AB-sham rats. The peptide level of ET-1 was also significantly higher in the LV of AB rats than in that of AB-sham rats. However, the expression of ET-1 mRNA in the LV of AR rats was similar to that of AR-sham rats. The present findings suggest that the production of ET-1 in the heart differs between pressure and volu...Continue Reading

Citations

May 10, 2001·Journal of the American College of Cardiology·L E SpiekerT F Lüscher
Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Robert P. OstrowskiAndrzej Kapuściński
Jan 15, 2011·American Journal of Hypertension·Magali CordaillatCaroline Rugale
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·L E SpiekerT F Lüscher
Feb 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Graham R LeeBarbara J McDermott
Feb 7, 2015·Journal of Cardiovascular Pharmacology·Ana F Branco, Bruce G Allen

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