Altered protein kinase a in brain of learned helpless rats: effects of acute and repeated stress

Biological Psychiatry
Yogesh DwivediJennifer Lyons

Abstract

Stress-induced learned helplessness (LH) in animals serves as a model of behavioral depression and some aspects of posttraumatic stress disorder. We examined whether LH behavior is associated with alterations in protein kinase A (PKA), a critical phosphorylating enzyme, how long these alterations persist after inescapable shock (IS), and whether repetition of IS prolongs the duration of LH behavior and changes in PKA. Rats were exposed to IS either on day 1 or twice, on day 1 and day 7. Rats were tested for escape latency on days 2 and 4 after day 1 IS or days 2, 8, and 14 after day 1 and day 7 IS. [(3)H]cAMP (cyclic adenosine monophosphate) binding, catalytic activity and expression of PKA subunits were determined in frontal cortex and hippocampus. Higher escape latencies were observed in rats tested on day 2 after single IS and on day 14 after repeated IS. Concurrently, reduced [(3)H]cAMP binding, PKA activity, and expression of selective PKA RIIbeta and Calpha and Cbeta subunits were observed in the brains of these rats. Repeated IS prolongs the duration of LH behavior, and LH behavior is associated with reductions in apparent activity and expression of PKA. These reductions in PKA may be critical in the pathophysiology of d...Continue Reading

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Citations

Sep 16, 2006·Experimental Brain Research·Sabine M GrüsserHerta Flor
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Yogesh Dwivedi, Ghanshyam N Pandey
Apr 24, 2012·Neuroscience Research·Gianluca SerafiniPaolo Girardi
Nov 24, 2011·Neurochemistry International·Ping ChenMeng-Yang Zhu
Apr 26, 2011·Journal of Chemical Neuroanatomy·Yogesh Dwivedi
Nov 6, 2013·The European Journal of Neuroscience·Jeyce W Quintino-dos-SantosLuiz C Schenberg
Jul 15, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Stephanie M GorkaStewart A Shankman
Aug 4, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Samuel TyanoAbraham Weizman
Dec 27, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·W N Marsden
Jul 4, 2009·The International Journal of Neuropsychopharmacology·Richard C SheltonDavid A Lewis
Nov 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yogesh DwivediGhanshyam N Pandey
Jan 6, 2021·International Journal of Molecular Sciences·Inês M AmaralRana El Rawas
Jul 10, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ya-Ting WangYi Zhang

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