Altered protein quality control contributes to noise-induced hearing loss

BioRxiv : the Preprint Server for Biology
Nopporn JongkamonwiwatJeffrey Savas

Abstract

Exposure to noise is the most common cause of hearing loss and impairment in more than 15% of adult Americans. Using quantitative proteomics, we tested how noise insults overhaul the cochlear proteome both acutely and recovery period. The intensities of noise exposure necessary to produce temporary or permanent threshold shifts (TTS, PTS) in young adult mice were determined at 94 and 105 dB SPL to elicits TTS and PTS, respectively. We quantified thousands of proteins and found a rapid increase rather than a decrease in the levels of proteins involved with protein homeostasis, myelin, cytoskeletal structures, and cell junctions such as the synapse. The vast majority of proteins with increased levels immediately after noise exposure showed normal levels after two weeks of recovery. Proteins involved in oxidative stress and neuroprotection had significantly increased levels only after the recovery period suggesting they play important role in regeneration. Interestingly, a small panel of mitochondrial proteins were significantly altered only in PTS conditions suggesting potential discrete protein mechanisms. Our discovery-based proteomic analysis extends the recent description of noise-induced cochlear synaptopathy and shows that ...Continue Reading

Related Concepts

Cochlear Diseases
Cytoskeleton
Hearing
Noise-induced Hearing Loss
Laboratory mice
Myelin Proteins
Natural Regeneration
Synapses
Oxidative Stress
American

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