PMID: 18406696Jul 1, 1995Paper

Altered pulsatile gonadotropin signaling in nutritional deficiency in the male

Trends in Endocrinology and Metabolism : TEM
M Bergendahl, J D Veldhuis

Abstract

Reproduction cannot occur without adequate nutrition. Diets that are nutritionally inadequate delay and disrupt the pubertal development of the reproductive processes of immature experimental animals and humans, and impair the function of the hypothalamic-pituitary-gonadal axis in adults. Although there is a general understanding of the linkages between nutrition and reproduction, there is a lack of detailed knowledge of the exact mechanisms that couple these two systems. The major effects of malnutrition on the hypothalamic-pituitary-gonadal axis reported in the literature are, for the most part, manifested as reduced gonadotropin secretion. Malnutrition results in decreased circulating gonadotropin concentrations. These changes in the reproductive system are associated with impaired gonadal function and subsequent secondary sex organ atrophy and lead, ultimately, to poor reproduction. Decreased hypothalamic release of gonadotropin-releasing hormone (GnRH) has been proposed as the most important etiologic factor for the fasting-induced suppression of pituitary-testicular function. In the human, hypogonadism and infertility develop in both sexes during chronic malnutrition. Most studies on the effects of malnutrition on the rep...Continue Reading

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Citations

Jun 28, 2003·Neurobiology of Aging·Johannes D Veldhuis
Oct 30, 2012·Journal of Pain and Symptom Management·Bruno GagnonDavid V Morris
May 26, 2009·Behavioural Brain Research·Tathiana A AlvarengaSergio Tufik
Aug 20, 2010·American Journal of Human Biology : the Official Journal of the Human Biology Council·Benjamin C TrumbleKathleen A O'Connor
Jun 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J D Veldhuis
Oct 29, 2015·Physiological Reports·Humberto Muzi-FilhoValeria M N Cunha
May 20, 2005·Endocrine Reviews·Jean M Kaufman, Alex Vermeulen
Oct 23, 2008·Endocrine Reviews·Johannes D VeldhuisSteven M Pincus
Jan 26, 2006·Endocrine Reviews·Johannes D VeldhuisCyril Y Bowers
Mar 11, 2008·Ageing Research Reviews·Bronwen MartinStuart Maudsley

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