Nov 16, 2019

Altered putamen and cerebellum connectivity among different subtypes of Parkinson's disease

CNS Neuroscience & Therapeutics
Bo ShenLi Zhang


Impairment of basal ganglia (BG)-thalamo-cortical circuit causes various symptoms of Parkinson's disease (PD). We investigated the functional connectivity (FC) patterns of putamen among PD subtypes and healthy control (HC) and explored their clinical significance. A total of 16 patients with tremor-dominant (TD) PD, 23 patients with postural instability and gait difficulty-dominant (PIGD) PD, and 31 HC that underwent functional magnetic resonance imaging were observed. Voxel-wise FC analysis was performed by computing correlation between bilateral putamen and other voxels within the brain. Correlation analysis was performed between FC strength and clinical symptoms. Compared with PIGD group, TD group showed increased FC between left putamen and right cerebellum lobule VI and cerebellum crus I, then we compared the cerebellum FC difference among the three groups. The cerebellum lobule VI FC difference was mainly involved in motor related cortex, and the cerebellum crus I FC difference was related to cognition areas. While compared with HC, TD and PIGD groups both had significant FC difference brain areas correlated with motor and cognition symptoms. The connectively of putamen and right cerebellum lobules VI and I showed positiv...Continue Reading

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Mentioned in this Paper

Simple Lobule of Cerebellum
Magnetic Resonance Imaging
Functional Behavioral Assessment
Central Lobule of Cerebellum
Sensorimotor Cortex
Putaminal Hemorrhage
Posterior Superior Ansiform Lobule of Cerebellum
Posture brand of calcium phosphate, tribasic

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