PMID: 8387374Feb 1, 1993

Altered ratios of beta-endorphin:beta-lipotropin released from anterior lobe corticotropes with increased secretory drive. II. Repeated stress

Journal of Neuroendocrinology
E YoungH Akil


A number of stimuli including acute footshock and electrically-induced seizures lead to release of beta-endorphin immunoreactivity from the anterior pituitary corticotropes. Gel filtration of this beta-endorphin immunoreactivity indicates that approximately 3-fold more beta-endorphin than beta-lipotropin is released into plasma following these acute stressors. A similar preponderance of beta-endorphin over beta-lipotropin is seen in the media of short-term anterior lobe cell suspensions stimulated with ovine corticotropin-releasing hormone. Previous studies indicated that footshock stress, when administered repeatedly, can increase the biosynthesis of anterior lobe proopiomelanocortin (POMC) as indicated by increased steady state adrenocorticotropin/beta-endorphin content as well as increased POMC mRNA levels and increased POMC biosynthesis and rate of processing as measured by pulse-labeling and pulse-chase studies. The goal of the present studies was to determine whether this increased biosynthetic drive results in an alteration in the end products secreted with repeated stress. Acute footshock in a rat which has received 14 days of chronic footshock releases proportionately more beta-lipotropin than is released in a naive ra...Continue Reading


Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A S LiottaD T Krieger
May 1, 1983·The Journal of Clinical Endocrinology and Metabolism·C A CahillH Akil

Related Concepts

ACTH (1-13)NH2
Molecular Sieve Chromatography
Corticotropin-Releasing Hormone
Electroconvulsive Shock
Pituitary Gland, Anterior

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