PMID: 3214750Sep 1, 1988Paper

Altered reactivity of the rat adrenal medulla

Brain Research Bulletin
D A CarbonaroP R Vulliet

Abstract

Previous studies have suggested that experimental alterations in adrenomedullary reactivity, i.e., changes in catecholamine release in response to a standard dose of acetylcholine, may be partially accounted for by changes occurring at the level of the adrenal medulla itself, independent of both the central nervous system and the innervation of the adrenal gland. The present study was designed to investigate the morphology of adrenal chromaffin cells in rats subjected to chronic hypoglycemia induced by long acting insulin, and to assess this morphology in terms of associated changes in catecholamine content and release. Surgically isolated, perfused adrenal gland preparations were utilized to characterize the functional release of catecholamines from the adrenal medulla. Pretreatment with long acting insulin resulted in a selective depletion of epinephrine stores and acetylcholine-mediated epinephrine release, but did not appear to significantly affect either the levels or the release of norepinephrine. The biochemical effects of long acting insulin persisted for several days after termination of the treatment, exhibiting a gradual recovery over a period of approximately 5 days. Electron microscopic examination of the adrenal c...Continue Reading

References

Jan 1, 1983·Neuroscience and Biobehavioral Reviews·E A Stone, R McCarty
May 1, 1961·The Journal of Physiology·R S COMLINE, M SILVER
Apr 1, 1965·Journal of Ultrastructure Research·L G ELFVIN

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Citations

May 1, 1995·Clinical and Experimental Hypertension : CHE·R R VollmerD J Edwards
Dec 29, 2000·Clinical and Experimental Hypertension : CHE·R R VollmerD J Edwards
Oct 1, 2014·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Branly O OrbanJoshua R Berlin
Dec 31, 1997·The American Journal of Physiology·R R VollmerD J Edwards

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