Altered rectal sensory response induced by balloon distention in patients with functional abdominal pain syndrome.

BioPsychoSocial Medicine
Tsukasa Nozu, Miwako Kudaira

Abstract

Functional abdominal pain syndrome (FAPS) has chronic unexplained abdominal pain and is similar to the psychiatric diagnosis of somatoform pain disorder. A patient with irritable bowel syndrome (IBS) also has chronic unexplained abdominal pain, and rectal hypersensitivity is observed in a majority of the patients. However, no reports have evaluated the visceral sensory function of FAPS precisely. We aimed to test the hypothesis that FAPS would show altered visceral sensation compared to healthy controls or IBS. The present study determined the rectal perceptual threshold, intensity of sensation using visual analogue scale (VAS), and rectal compliance in response to rectal balloon distention by a barostat in FAPS, IBS, and healthy controls. First, the ramp distention of 40 ml/min was induced and the thresholds of discomfort, pain, and maximum tolerance (mmHg) were measured. Next, three phasic distentions (60-sec duration separated by 30-sec intervals) of 10, 15 and 20 mmHg were randomly loaded. The subjects were asked to mark the VAS in reference to subjective intensity of sensation immediately after each distention. A pressure-volume relationship was determined by plotting corresponding pressures and volumes during ramp distent...Continue Reading

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Citations

Aug 10, 2010·Current Gastroenterology Reports·Madhusudan Grover, Douglas A Drossman
Jun 20, 2014·Paediatric Drugs·Adrian Miranda, Miguel Saps
Jan 6, 2011·Alimentary Pharmacology & Therapeutics·A D Sperber, D A Drossman
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Sep 7, 2014·Journal of the Royal Society of Medicine·Adam D Farmer, Qasim Aziz
Nov 15, 2012·Scandinavian Journal of Gastroenterology·Bodil Roth, Bodil Ohlsson
Mar 1, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Dipesh H Vasant, Peter J Whorwell
Jun 24, 2021·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Hee Jin Kim, Hyun Jin Kim

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