PMID: 3770316Dec 1, 1986Paper

Altered red and white blood cell rheology in type II diabetes

Diabetes
E Ernst, A Matrai

Abstract

Twenty-three patients suffering from type II, non-insulin-dependent diabetes were compared with matched controls. Suspensions with standardized white and red cell counts were filtered in a novel device capable of discriminating filter occlusion and cell transit time. Results confirm previous studies indicating that red cell deformability is impaired in diabetes. According to our findings, this may be caused by a slight overall loss of red cell fluidity together with the existence of a subpopulation of more markedly rigid erythrocytes. Furthermore, we demonstrate that white cell filterability is reduced in type II diabetes. This could be due to decreased white cell deformability, increased white cell adhesion, or both. Analysis of diabetic subgroups indicates that the white cell rheology is impaired to a greater extent in patients taking oral antidiabetic drugs than in patients controlled by diet alone. Altered white cell rheology could help to explain the pathological blood cell filterability frequently reported in diabetes. More important, impaired white cell rheology might significantly contribute to microcirculatory flow abnormalities jeopardizing O2 exchange in the terminal vascular bed.

Citations

Oct 1, 1993·Diabetes/metabolism Reviews·D A GreeneS A Lattimer
Oct 25, 2002·Diabetes/metabolism Research and Reviews·Jiro NakamuraNigishi Hotta
Jan 16, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ioannis K PetropoulosIssidora S Papassideri
Aug 7, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Shih-Yi HuangDer-Zen Liu
Aug 26, 2000·Journal of Diabetes and Its Complications·J Y HokamaP F McDonagh
May 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·S M MacRury, G D Lowe
Apr 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·S M MacRuryG D Lowe
May 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·M D Flynn, J E Tooke
Apr 21, 2005·Kidney International·Laurie Rebsomen, Michel Tsimaratos
Oct 26, 2000·The British Journal of Ophthalmology·K G SchmidtH P Hammes
Feb 1, 1994·The American Journal of the Medical Sciences·M S KirkmanD L Hatchell
Jul 6, 2004·Clinical Physiology and Functional Imaging·John Wahren
Apr 5, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·B Chong-MartinezH J Meiselman
Dec 7, 2010·Pediatric Diabetes·Patrizia LuppiJohn Wahren
Aug 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·D K YueJ R Turtle
Sep 1, 1987·Baillière's Clinical Haematology·G D Lowe
Jun 1, 1992·Atherosclerosis·W Koenig, E Ernst
Jul 1, 1997·Microvascular Research·K MiyamotoY Honda
Aug 2, 2008·Experimental Diabetes Research·T ForstA Pfützner
Aug 13, 2010·Diabetes Research and Clinical Practice·D Simmons
Aug 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·P J WatersR Eisenthal
Jan 1, 1988·Stroke; a Journal of Cerebral Circulation·G CiuffettiR Lombardini
May 19, 2006·Journal of the American Podiatric Medical Association·Javier La FontainePaula K Shireman
Jul 15, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Justin Kok Soon TanRupesh Agrawal
Nov 4, 2009·Journal of Diabetes Science and Technology·Young I ChoDaniel J Cho
Aug 25, 2006·The International Journal of Lower Extremity Wounds·Anna Korzon-Burakowska, Michael Edmonds
Jun 22, 2018·Molecular Biology of the Cell·Raya SorkinGijs J L Wuite
Sep 11, 2003·Journal of Wound Care·P Murphie

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