Altered regulation of CD200 receptor in monocyte-derived macrophages from individuals with Parkinson's disease.

Neurochemical Research
Xiao-Guang LuoJian-Qing Ding

Abstract

Microglia are the representative myeloid cells in the brain, and their over-activation plays an important role in the pathogenesis of Parkinson's disease (PD). Microglia activation is believed to be regulated by the CD200-CD200R signaling. As the peripheral counterpart of microglia, monocyte-derived macrophages (MDMs) share the same progenitor and antigen markers, and they have similar biological behaviors and mirror microglial function in the brain. Here, we studied CD200R expression and its regulation in MDMs from 32 PD cases, 27 age-matched old controls, and 28 young controls. We found that the basal CD200R expression is similar in MDMs from young control, old control and PD patients. However, the induction of CD200R expression in MDMs under various conditions is impaired in the old groups, especially in PD patients. There was a selective decrease in CD200R expression induced by co-culture with dying PC12 cells in MDMs from PD cases, as compared with MDMs from the age-matched controls. We also found that the inducible CD200R expression correlated inversely with the onset age of PD and to tumor necrosis factor-alpha (TNF-alpha) released from MDMs. These results suggest an intrinsic abnormality in the CD200-CD200R signaling in...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Aug 1, 1994·Clinical Neuropharmacology·D A LoefflerP A LeWitt
Jun 20, 2002·Trends in Immunology·A Neil BarclayMarion H Brown
Jan 18, 2003·Progress in Neurobiology·C F OrrG M Halliday
Feb 22, 2003·The Journal of Comparative Neurology·Ishar DalmauBernardo Castellano
Jul 30, 2003·Journal of Leukocyte Biology·Andrew D DickJanet Liversidge
Aug 14, 2003·Trends in Pharmacological Sciences·Hui Ming GaoJau Shyong Hong
Aug 20, 2003·Archives of Neurology·Honglei ChenAlberto Ascherio
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gavin J WrightA Neil Barclay
Jan 13, 2004·Neurotoxicity Research·Carlos BarciaMaría-Trinidad Herrero
Oct 16, 2004·The Journal of Investigative Dermatology·Michael D RosenblumRobert L Truitt
Jan 5, 2005·Experimental Neurology·Ranjita BetarbetJ Timothy Greenamyre
May 14, 2005·Neurobiology of Aging·Matthew G FrankSteven F Maier
Oct 4, 2005·Neurological Research·Wolfgang J StreitChristopher L Mariani
Sep 6, 2006·Experimental & Molecular Medicine·Yoon Seong Kim, Tong H Joh
Sep 15, 2006·Neurochemistry International·Xi-Jin WangSheng-Di Chen
Apr 26, 2007·The American Journal of Pathology·Tanuja ChitnisSamia J Khoury
Aug 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony LyonsMarina A Lynch
Sep 21, 2007·Annals of Neurology·Nathalie KoningInge Huitinga
Oct 24, 2007·Trends in Neurosciences·Knut BiberHendrikus W G M Boddeke
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Xi-Jin WangSheng-Di Chen
Feb 19, 2008·The FEBS Journal·Mügen Terzioglu, Dagmar Galter
Feb 19, 2008·The FEBS Journal·Andrea C Belin, Marie Westerlund
Mar 4, 2008·Brain Research Reviews·Frank J S Lee, Fang Liu
Jul 22, 2008·Parkinsonism & Related Disorders·Alessandro PrigioneCarlo Ferrarese
Dec 17, 2008·Annals of the New York Academy of Sciences·Chun ZhouSerge Przedborski

❮ Previous
Next ❯

Citations

Sep 3, 2011·Surgical Neurology International·Russell L Blaylock, Joseph Maroon
Aug 27, 2014·Molecular Therapy. Nucleic Acids·Aaron ProdeusJean Gariépy
Jun 17, 2011·Multiple Sclerosis : Clinical and Laboratory Research·S RossiD Centonze
Nov 27, 2018·The European Journal of Neuroscience·Malú G Tansey, Marina Romero-Ramos
Oct 27, 2017·Journal of Neuroscience Research·Neeraj Joshi, Sarika Singh
Mar 20, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S LinJ Ding
Nov 16, 2019·Current Neuropharmacology·Katarzyna ChameraAgnieszka Basta-Kaim
Mar 9, 2021·Frontiers in Immunology·Tizibt Ashine BogaleArianna Bellucci
Nov 20, 2021·Cellular and Molecular Neurobiology·Yu TianZhaoliang Su

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.