Altered regulation of energy homeostasis in older rats in response to thyroid hormone administration

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Stephane WalrandK S Nair

Abstract

Hyperthyroidism causes increased energy intake and expenditure, although anorexia and higher weight loss have been reported in elderly individuals with hyperthyroidism. To determine the effect of age on energy homeostasis in response to experimental hyperthyroidism, we administered 200 μg tri-iodothyronine (T3) in 7- and 27-mo-old rats for 14 d. T3 increased energy expenditure (EE) in both the young and the old rats, although the old rats lost more weight (147 g) than the young rats (58 g) because of the discordant effect of T3 on food intake, with a 40% increase in the young rats, but a 40% decrease in the old ones. The increased food intake in the young rats corresponded with a T3-mediated increase in the appetite-regulating proteins agouti-related peptide, neuropeptide Y, and uncoupling protein 2 in the hypothalamus, but no increase occurred in the old rats. Evidence of mitochondrial biogenesis in response to T3 was similar in the soleus muscle and heart of the young and old animals, but less consistent in old plantaris muscle and liver. Despite the comparable increase in EE, T3's effect on mitochondrial function was modulated by age in a tissue-specific manner. We conclude that older rats lack compensatory mechanisms to inc...Continue Reading

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Citations

Dec 3, 2014·Experimental Gerontology·A I Bozhkov, Yu V Nikitchenko
Jun 29, 2016·The Journal of Investigative Dermatology·Silvia VidaliRalf Paus
Feb 17, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kathrin EngelsDagmar Führer
Mar 19, 2019·International Journal of Endocrinology and Metabolism·Qianqian SongBin Cui
Dec 3, 2021·Biological & Pharmaceutical Bulletin·Masaru DoshiYutaka Hirashima-Akae

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