Altered regulation of glutamate release and decreased functional activity and expression of GLT1 and GLAST glutamate transporters in the hippocampus of adolescent rats perinatally exposed to Delta(9)-THC

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
P CastaldoS Amoroso

Abstract

The long-term effects of perinatal Delta(9)-tetrahydrocannabinol (Delta(9)-THC) exposure - from gestational day (GD) 15 to postnatal day (PND) 9 - on hippocampal glutamatergic neurotransmission were studied in slices from the 40-day-old offspring of Delta(9)-THC exposed (Delta(9)-THC-rats) and vehicle-exposed (control) dams. Basal and in K+-evoked endogenous hippocampal glutamate outflow were both significantly decreased in Delta(9)-THC-rats. The effect of short Delta(9)-THC exposure (0.1microM) on K(+)-evoked glutamate release disclosed a loss of the stimulatory effect of Delta(9)-THC on hippocampal glutamate release in Delta(9)-THC-rats, but not in controls. In addition, l-[(3)H]-glutamate uptake was significantly lower in hippocampal slices from Delta(9)-THC-rats, where a significant decrease in glutamate transporter 1 (GLT1) and glutamate/aspartate transporter (GLAST) protein was also detected. Collectively, these data demonstrate that perinatal exposure to cannabinoids induces long-term impairment in hippocampal glutamatergic neurotransmission that persist into adolescence.

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Citations

Dec 3, 2014·Neurochemistry International·Esperanza JiménezCecilio Giménez
Nov 21, 2014·Nature Reviews. Neuroscience·Mauro MaccarroneTibor Harkany
Jan 23, 2016·British Journal of Pharmacology·África FloresFernando Berrendero
Jun 13, 2017·The International Journal of Neuropsychopharmacology·Sade Spencer, Peter W Kalivas
Oct 8, 2020·International Journal of Molecular Sciences·Diogo M LourençoSara Xapelli
Feb 2, 2021·Frontiers in Psychiatry·Mina G NashedSteven R Laviolette
Nov 27, 2020·Frontiers in Psychiatry·Francisco NavarreteJorge Manzanares
Oct 15, 2020·International Journal of Molecular Sciences·Vidyasagar Naik BukkeTommaso Cassano
Oct 13, 2019·Trends in Neurosciences·Andrew F ScheyerOlivier J J Manzoni
May 23, 2021·Nature Reviews. Neuroscience·Anissa BaraYasmin L Hurd

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