Altered regulation of parathyroid hormone secretion by calcium in pregnant and lactating rats

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
V L SchultzS U Toverud

Abstract

We have previously shown that the serum parathyroid hormone (PTH) concentration in lactating (L) rats is not suppressed by high serum Ca2+ to the same extent as in nonmated (NM) rats. To investigate further Ca2+ regulation of PTH secretion, parathyroid cells from NM rats and rats in late pregnancy and at peak lactation were dispersed and incubated for 2 h in medium containing 0.52-2.05 mM Ca2+. Medium PTH was assayed with a homologous immunoradiometric assay (IRMA). At the two highest Ca2+ levels (1.81 and 2.05 mM), medium PTH was significantly higher (p = 0.031) for cells from L rats than for cells from NM rats. In contrast, significantly less (p < 0.001) PTH was secreted for the L group versus the NM group at medium Ca2+ values of 1.27 and 1.46 mM. Estimated set points for L and NM groups were 1.17 mM and 1.35 mM, respectively, corresponding closely to the prevailing serum Ca2+ for these two groups. Consistent with the present in vitro data, high serum PTH (> 40 pg/ml) in L rats occurred only at serum Ca2+ values below 1.27 mM. Elevated serum PTH at lower serum Ca2+ levels was also seen in pregnant rats. Dispersed parathyroid cells from 20- to 21-day pregnant rats secreted significantly more PTH (p = 0.028) than cells from NM...Continue Reading

References

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Citations

Feb 18, 2004·The Journal of Clinical Investigation·Joshua VanHoutenJohn J Wysolmerski
Jun 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A BoassS U Toverud
Dec 31, 1997·Endocrine Reviews·C S Kovacs, H M Kronenberg
Oct 6, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna KosickaDerek Renshaw
Feb 17, 2000·The Journal of Veterinary Medical Science·F IchikawaK Saito

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