Altered regulation of renal interstitial hydrostatic pressure and the renal renin-angiotensin system in the absence of atrial natriuretic peptide

Journal of Hypertension
P F O'TierneyStephen C Pang

Abstract

Although it has been well established that atrial natriuretic peptide gene-disrupted (ANP-/-) mice are a useful model of salt-sensitive hypertension, surprisingly little is known about the control of their intrarenal renin-angiotensin system (RAS) and pressure-natriuresis mechanism, key components in blood pressure, fluid and electrolyte regulation. The aim of this study was to determine whether ANP disruption results in changes in the renal and adrenal local RAS and the acute pressure-natriuresis mechanism. Renal and adrenal renin, angiotensin type 1 (AT1)(A and B) and angiotensin type 2 (AT2) receptor messenger RNA expression levels were determined by northern blotting or real time reverse transcriptase-polymerase chain reaction. Plasma aldosterone and renal and adrenal angiotensin II peptide levels were determined by radioimmunoassay. To examine the acute pressure-natriuresis response, changes in renal interstitial hydrostatic pressure (RIHP) were assessed after manipulations of renal arterial pressure (RAP) in anaesthetized mice. Renal and adrenal renin mRNA and angiotensin II levels were lower in ANP-/- and +/- mice compared with +/+mice. ANP-/- mice also had greater renal AT1A and adrenal AT2 mRNA levels compared with the...Continue Reading

References

Jun 1, 1977·Acta Physiologica Scandinavica·B FolkowS E Ricksten
Aug 1, 1992·Canadian Journal of Physiology and Pharmacology·S Kaufman
Jan 11, 1992·Physiological Reviews·A W Cowley
Oct 1, 1991·Canadian Journal of Physiology and Pharmacology·P WeidmannS G Shaw
Oct 1, 1990·The Journal of Clinical Endocrinology and Metabolism·P FerrariS Shaw
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·H DeneJ P Rapp
Dec 1, 1986·Hypertension·K BabaJ P Rapp
Mar 1, 1996·Hypertension·M H Weinberger
Nov 14, 1997·Kidney International·V GrossF C Luft
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·P M OliverO Smithies
Apr 5, 2000·The Journal of Clinical Investigation·C E GariepyM Yanagisawa
May 17, 2001·Molecular and Cellular Biochemistry·M Y TseS C Pang
Sep 13, 2001·American Journal of Physiology. Renal Physiology·S J ShiK N Pandey
Apr 23, 2002·Hypertension·Naomi D L FisherGordon H Williams
Dec 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David L Mattson
Oct 6, 2005·American Journal of Hypertension·Ali A KhraibiReinhart B Billiar

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Citations

Oct 31, 2007·Hypertension·Stephane L BourqueMichael A Adams
Mar 12, 2016·Experimental & Molecular Medicine·James Won Suk JahngGary Sweeney
Jan 6, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Aiilyan K HoungGuy L Reed
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Dec 31, 2010·Journal of Hypertension·Yoshiro NaitoTohru Masuyama

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