Altered regulation of the 5-HT system in the brain of MAO-A knock-out mice

The European Journal of Neuroscience
A EvrardJ Adrien

Abstract

Genetic deficiency of monoamine oxidase-A (MAO-A) induces major alterations of mood and behaviour in human. Because serotonin (5-HT) is involved in mood regulation, and MAO-A is responsible for the catabolism of 5-HT, we investigated 5-HT mechanisms in knock-out mice (2-month-old) lacking MAO-A, using microdialysis, electrophysiological, autoradiographic and molecular biology approaches. Compared to paired wild-type mice, basal extracellular 5-HT levels were increased in ventral hippocampus (+202%), frontal cortex (+96%) and dorsal raphe nucleus (DRN, +147%) of MAO-A mutant mice. Conversely, spontaneous firing rate of 5-HT neurons in the DRN (recorded under chloral hydrate anaesthesia) was approximately 40% lower in mutants. Acute 5-HT reuptake blockade by citalopram (0.2 and 0.8 mg/kg i.v.) produced a much larger increase in extracellular 5-HT levels (by approximately 4 fold) and decrease in DRN neuronal firing (with a approximately 4.5 fold decrease in the drug's ED50) in MAO-A knock-out mice, which expressed lower levels of the 5-HT transporter throughout the brain (-13 to -34% compared to wild-type levels). The potency of the 5-HT1A agonist 8-OH-DPAT to produce hypothermia and to reduce the firing of DRN serotoninergic neur...Continue Reading

References

Oct 8, 1992·Nature·P D Siebert, J W Larrick
Oct 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P M Whitaker-AzmitiaC Clarke
Jul 1, 1994·Trends in Pharmacological Sciences·P Blier, C de Montigny
Dec 31, 1996·Brain Research. Molecular Brain Research·A S ChangR D Blakely
Jan 16, 1998·European Journal of Pharmacology·V FabreA M Laporte
Nov 11, 1998·European Journal of Pharmacology·I Hervás, F Artigas
Aug 5, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·H Y Meltzer

❮ Previous
Next ❯

Citations

Feb 3, 2005·Behavior Genetics·Scott F Stoltenberg
May 25, 2002·The European Journal of Neuroscience·Catarina A OwessonJonathan A Stamford
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Klaus-Peter LeschLise Gutknecht
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian J MickeyJon-Kar Zubieta
Jan 19, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sean C GodarMarco Bortolato
Jul 21, 2009·Respiratory Physiology & Neurobiology·C RealP Escourrou
Dec 30, 2008·Brain Research Bulletin·Régis GrailheIsabelle Cloëz-Tayarani
Oct 16, 2007·Neurochemistry International·Allan V KalueffDennis L Murphy
Nov 19, 2003·The European Journal of Neuroscience·Saoussen BoualiJoëlle Adrien
Aug 26, 2006·The European Journal of Neuroscience·Grégory ConductierValérie Compan
May 12, 2004·Epilepsy Research·G Campbell TeskeyRichard H Dyck
Apr 28, 2006·Neuroscience Letters·Rainald MössnerIsabelle Seif
Jun 1, 2005·Neuroscience and Biobehavioral Reviews·Alexandre UraniPeter Gass
Apr 23, 2015·The International Journal of Neuropsychopharmacology·Leonardo MunariPatrizio Blandina
Sep 8, 2012·The International Journal of Neuropsychopharmacology·Dara M CannonWayne C Drevets
Dec 17, 2009·The International Journal of Neuropsychopharmacology·Cedric MombereauJulie A Blendy
Oct 25, 2016·Trends in Pharmacological Sciences·Jacob P R JacobsenMarc G Caron
Mar 16, 2018·Expert Opinion on Therapeutic Targets·Alexander V KulikovNina K Popova
Mar 26, 2004·Nature Reviews. Drug Discovery·Ma-Li Wong, Julio Licinio
Apr 15, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nina K Popova
Apr 19, 2007·Aggressive Behavior·Galina B VishnivetskayaNina K Popova
Jan 22, 2019·Expert Opinion on Therapeutic Targets·Nina K Popova, Vladimir S Naumenko
Feb 10, 2006·Expert Review of Neurotherapeutics·Céline FaureNasser Haddjeri
Aug 2, 2020·The Journal of Experimental Biology·Constance PierreSylvie Rétaux
Jul 28, 2007·Neuroscience and Behavioral Physiology·N K PopovaI Z Plyusnina
Aug 27, 2005·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·V S NaumenkoN K Popova
Dec 21, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Dongmei DuanPing Liu
Feb 6, 2020·Environmental Science and Pollution Research International·Mona Abdel-RahmanAhmed E Abdel Moneim
Jun 9, 2021·Chemical Communications : Chem Comm·Chuanping ZhangYang Tian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.