Altered regulation of the T-cell system in patients with CRPS

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Jens HeynBenjamin Luchting

Abstract

The aim of this study was to investigate T-cell subsets and immunomodulatory factors in patients with complex regional pain syndrome (CRPS). We found decreased numbers of pro-inflammatory Th17 cells in patients with CRPS as compared to healthy volunteers. The expression of Th17 related RORγT mRNA was also significantly decreased. Patients with CRPS showed an increased proportion of CD39+ Tregs. CD39 is a known inhibitor of Th17 cell differentiation. Systemic cytokine levels were almost unchanged in patients with CRPS. These findings suggest that the decrease in Th17 cells in CRPS is regulated by an increase in CD39+ Tregs and that this anti-inflammatory T-cell shift may be a mechanism to control inflammation in CRPS. GERMAN CLINICAL TRIAL REGISTER: Registration Trial DRKS00005954.

References

May 1, 2002·Anesthesiology·Srinivasa N Raja, Theodore S Grabow
Mar 17, 2004·Immunology Letters·Frank J P M HuygenFreek J Zijlstra
Sep 17, 2004·Nature·Victor Ambros
Jul 6, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·R Norman HardenPeter R Wilson
Feb 2, 2008·Neuroimmunomodulation·Ines KaufmannManfred Thiel
Aug 10, 2010·Anesthesiology·Stephen Bruehl
Nov 15, 2011·Journal of Translational Medicine·Irina A OrlovaSeena K Ajit
Aug 15, 2014·PloS One·Benjamin LuchtingShahnaz Christina Azad
Jan 23, 2015·Journal of Neuroinflammation·Benjamin LuchtingShahnaz Christina Azad
Jun 22, 2017·Mediators of Inflammation·Krishna D BharwaniFrank J P M Huygen

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Citations

Oct 2, 2019·Frontiers in Molecular Neuroscience·Geoffroy LaumetAnnemieke Kavelaars
Apr 1, 2021·Molecular Pain·Amrita Prasad Md, Krishnan Chakravarthy Md

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Methods Mentioned

BETA
flow cytometry
PCR

Software Mentioned

Relative Quantification
SigmaStat

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