Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase

The Journal of Physiology
D D KlineN R Prabhakar


1. The role of endogenous nitric oxide (NO) generated by neuronal nitric oxide synthase (NOS-1) in the control of respiration during hypoxia and hypercapnia was assessed using mutant mice deficient in NOS-1. 2. Experiments were performed on awake and anaesthetized mutant and wild-type control mice. Respiratory responses to varying levels of inspired oxygen (100, 21 and 12% O2) and carbon dioxide (3 and 5% CO2 balanced oxygen) were analysed. In awake animals, respiration was monitored by body plethysmograph along with oxygen consumption (VO2), CO2 production (VCO2) and body temperature. In anaesthetized, spontaneously breathing mice, integrated efferent phrenic nerve activity was monitored as an index of neural respiration along with arterial blood pressure and blood gases. Cyclic 3',5'-guanosine monophosphate (cGMP) levels in the brainstem were analysed by radioimmunoassay as an index of nitric oxide generation. 3. Unanaesthetized mutant mice exhibited greater respiratory responses during 21 and 12% O2 than the wild-type controls. Respiratory responses were associated with significant decreases in oxygen consumption in both groups of mice, and the magnitude of change was greater in mutant than wild-type mice. Changes in CO2 pro...Continue Reading


Aug 1, 1975·The American Journal of Physiology·S Lahiri
Jan 1, 1978·Advances in Experimental Medicine and Biology·N S CherniackF F Kao
Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Oct 1, 1992·Journal of Applied Physiology·A J ThomasKingman P Strohl
Aug 1, 1991·European Journal of Clinical Investigation·S Moncada, E A Higgs
Apr 9, 1990·Biochimica Et Biophysica Acta·C H ChangF Murad
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Oct 1, 1970·Respiration Physiology·D Bartlett, S M Tenney
Nov 1, 1982·The Journal of Physiology·H H Loeschcke
Oct 15, 1993·The Journal of Comparative Neurology·Z Z WangL J Stensaas
Mar 1, 1994·Stroke; a Journal of Cerebral Circulation·F M Faraci, J E Brian
May 1, 1994·Neuroscience·Z Z WangS Fidone
Jun 1, 1994·Cell and Tissue Research·B HöhlerWolfgang Kummer
Jul 14, 1995·Journal of the Autonomic Nervous System·P A GrimesS Lahiri
Oct 15, 1993·Brain Research·N R PrabhakarM A Haxhiu
Jan 1, 1995·Respiration Physiology·E H Schlenker, G A Farkas
Sep 1, 1995·Respiration Physiology·M A HaxhiuN S Cherniack
Jan 1, 1995·Annual Review of Cell and Developmental Biology·S R Jaffrey, S H Snyder
Aug 1, 1996·Journal of Applied Physiology·H Gautier
Jan 1, 1997·Journal of Applied Physiology·Luc J TeppemaC Olievier
Jul 1, 1962·Physiological Reviews·P DEJOURS


Feb 22, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·N R Prabhakar, G L Semenza
Feb 22, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·G L Semenza, N R Prabhakar
Aug 30, 2000·Respiration Physiology·D GozalNarong Simakajornboon
Sep 1, 2000·Respiration Physiology·N R Prabhakar, J L Overholt
Jun 29, 1999·Respiration Physiology·N R Prabhakar
Jun 19, 2001·The International Journal of Biochemistry & Cell Biology·S LahiriD G Buerk
Jun 24, 2003·The International Journal of Biochemistry & Cell Biology·S Lahiri, Robert E Forster
Jul 5, 2001·Sleep Medicine·C Gaultier, C Guilleminault
Jul 20, 2002·Respiratory Physiology & Neurobiology·M Mosqueira, R Iturriaga
Jun 18, 2003·Respiratory Physiology & Neurobiology·C G Tankersley
Jun 18, 2003·Respiratory Physiology & Neurobiology·Kingman P Strohl
Oct 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Albert K Y TsuiGregory M T Hare
May 19, 2007·Antioxidants & Redox Signaling·D G Buerk
Jan 11, 2005·American Journal of Respiratory and Critical Care Medicine·Claudia ReinhardHolger Schulz
Jun 21, 2003·American Journal of Respiratory Cell and Molecular Biology·Jeroen Van GenechtenDirk Adriaensen
Nov 9, 2005·The Journal of Clinical Investigation·Michael E WardPhilip A Marsden
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·D D KlineN R Prabhakar
Jul 9, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Renata Galvão de LimaLusiane Maria Bendhack
Oct 2, 2012·Seminars in Cell & Developmental Biology·Colin A Nurse, Nikol A Piskuric
Nov 10, 2011·Journal of Neuroscience Methods·Livia FerrariAlessandro Gozzi
May 11, 2011·Respiratory Physiology & Neurobiology·Sam ChaiKingman P Strohl
Aug 29, 2009·Respiratory Physiology & Neurobiology·Jeanne AmielC Goridis
Apr 18, 2009·Respiratory Physiology & Neurobiology·Erica M Granjeiro, Benedito H Machado
Sep 13, 2008·Respiratory Physiology & Neurobiology·Stephen R ReevesD Gozal
Aug 5, 2008·Respiratory Physiology & Neurobiology·J Gallego, S Dauger
Mar 14, 2007·Respiratory Physiology & Neurobiology·Verónica A Campanucci, Colin A Nurse
Nov 2, 2011·Experimental Physiology·Naoto TsuchiyaIkuo Homma
Sep 3, 2005·Progress in Biophysics and Molecular Biology·S LahiriN R Prabhakar
Jul 2, 2015·Respiratory Physiology & Neurobiology·S F Perry, V Tzaneva
May 1, 2012·Respiratory Physiology & Neurobiology·Verónica A CampanucciColin A Nurse
Jun 13, 2014·American Journal of Respiratory Cell and Molecular Biology·Lisa A PalmerStephen J Lewis
Mar 22, 2007·Respiratory Physiology & Neurobiology·H D Schultz, Yu-Long Li
Jul 7, 2011·Respiratory Physiology & Neurobiology·Lucas M DonovanKingman P Strohl
Apr 25, 2000·Clinical and Experimental Pharmacology & Physiology·N Marsh, A Marsh
Jun 15, 2004·Journal of Applied Physiology·Masahiko IzumizakiIkuo Homma
Apr 22, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Jeroen Van GenechtenDirk Adriaensen
Aug 6, 2005·Circulation Research·David J Paterson
Oct 27, 2018·Journal of Cachexia, Sarcopenia and Muscle·Daryl P FieldsGordon S Mitchell
May 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jorge SolizMax Gassmann
Mar 27, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jorge SolizMax Gassmann
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Viviana ValdésR Iturriaga
Jul 11, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T Luise KingEileen M Hasser
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan
Oct 25, 2007·Biochemical Society Transactions·O PierreficheJ F R Paton
Nov 26, 1999·Current Opinion in Pulmonary Medicine·C G Tankersley
Apr 6, 2000·Journal of Applied Physiology·D D KlineN R Prabhakar
Apr 6, 2000·Journal of Applied Physiology·D F Donnelly, R Rigual
Feb 13, 2001·Journal of Applied Physiology·J M KramerT G Waldrop
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Coert J ZuurbierCan Ince
Feb 14, 2002·Journal of Applied Physiology·Fang HanKingman P Strohl
Jun 14, 2000·Journal of Applied Physiology·C G TankersleyA H Schnell
Apr 12, 2003·Clinical and Experimental Pharmacology & Physiology·Sharyn M FitzgeraldGöran Bergström
Jun 14, 2000·Journal of Applied Physiology·D F Donnelly
Aug 12, 2003·Journal of Applied Physiology·Edwin R PriceKingman P Strohl
Jul 18, 2000·American Journal of Physiology. Cell Physiology·S Rao, A S Verkman
Jul 20, 1999·Journal of Applied Physiology·H Gautier, C Murariu
Aug 17, 2002·Journal of Applied Physiology·Shyam SubramanianKingman P Strohl
Jan 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·N RamanantsoaJ Gallego

Related Concepts

Nos1 protein, mouse
Diastolic Blood Pressure
Brain Stem
Carbon Dioxide
Chemoreceptor Cells
Crosses, Genetic
Cyclic GMP
Mice, Inbred C57BL

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.