Altered response of strain of Schistosoma mansoni to oxamniquine and praziquantel

Memórias do Instituto Oswaldo Cruz
Patrícia Ivana Pires Bonesso-Sabadini, L C de Souza Dias

Abstract

The susceptibility of a fourth generation Ouh strain (Paranapanema Valley, São Paulo, Brazil) of Schistosoma mansoni to oxamniquine (OXA) and praziquantel (PZQ) was studied. Ten groups of 13 female albino mice each were infected with 70 cercariae per animal. These mice were medicated orally on the 50th day after infection. Five groups were given OXA doses of 0, 100, 200, 300 and 400 mg/kg (single doses) and the rest were treated with PZQ doses of 0, 100, 200, and 250 mg/kg/5 days. Each group was sub-divided: 8 animals underwent perfusion after 15 days treatment, 5 mice followed up for oviposition and their feces were tested every 15 days for miracidia hatching. The efficacy of the OXA doses of 100 and 200 mg/kg was 66% and 91.4%, respectively and for the 100 mg/kg PZQ dose it was 90.1%. The follow-up groups with 100 and 200 mg/kg of OXA and PZQ, 100 and 150 mg/kg, showed that they re-established the oviposition after a period of 60 to 75 days of treatment. The ED50 was 69.6 mg/kg OXA and 39.4 mg/kg PZQ. The results show the tolerance of the Ouh strain to a dose of 100 mg with both drugs and they appoint the need for a dose review during the follow up of the oviposition and in monitoring phenomena in the field.

References

Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P J BrindleyA Sher
Oct 1, 1989·Memórias do Instituto Oswaldo Cruz·A C Silveira
Mar 1, 1988·Revista Do Instituto De Medicina Tropical De São Paulo·L C DiasG C Coles
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·G C ColesN Katz
Jan 1, 1968·Advances in Parasitology·J Pellegrino, N Katz
Jun 4, 1971·Science·S H Rogers, E Bueding
Aug 1, 1995·The American Journal of Tropical Medicine and Hygiene·F F StelmaB Gryseels
Jan 1, 1993·Memórias do Instituto Oswaldo Cruz·K M DrescherG C Coles
Jan 1, 1993·Molecular and Biochemical Parasitology·E Dias NetoA J Simpson
Oct 1, 1994·Memórias do Instituto Oswaldo Cruz·M L PenidoP M Coelho
Aug 1, 1996·The American Journal of Tropical Medicine and Hygiene·M IsmailJ L Bennett
May 1, 1997·Experimental Parasitology·P G FallonM J Doenhoff
Sep 1, 2000·Revista Da Sociedade Brasileira De Medicina Tropical·N Katz, S V Peixoto
Apr 20, 2002·Current Opinion in Infectious Diseases·Donato Cioli
Mar 1, 1956·Annals of Tropical Medicine and Parasitology·J HILL

❮ Previous
Next ❯

Citations

Oct 12, 2012·Parasitology Research·Wei WangYou-Sheng Liang
Jan 30, 2013·Parasitology Research·Wei Wu, Yixin Huang
Oct 23, 2013·Parasitology Research·Hong-Jun LiWei Wang
Sep 19, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Liliani Salum Alves MoreiraDavid Lee Nelson
May 14, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Joanne P WebsterAlan Fenwick
Sep 17, 2013·Memórias do Instituto Oswaldo Cruz·Naftale KatzNeusa Araújo
Feb 13, 2007·International Journal of Pharmaceutics·Sávia Caldeira de AraújoMônica Cristina de Oliveira
Nov 11, 2008·Acta Tropica·Marcus Luiz de Oliveira PenidoDavid Lee Nelson
Jan 23, 2015·Pharmaceutical Biology·Wael M LotfyHanaa M Abu El Einin
May 20, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Pierre EchaubardBruce A Wilcox
Feb 28, 2017·Journal of Medicinal Chemistry·Gebremedhin S HailuAntonello Mai
Nov 5, 2003·Memórias do Instituto Oswaldo Cruz·Lanny Cristina Burlandy-SoaresRicardo Mario Ciaravolo
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Conrad V SimobenWolfgang Sippl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

Memórias do Instituto Oswaldo Cruz
M L PenidoP M Coelho
Memórias do Instituto Oswaldo Cruz
M H AndradeD L Nelson
© 2021 Meta ULC. All rights reserved