Altered resting activity patterns and connectivity in individuals with complex regional pain syndrome.

Human Brain Mapping
Flavia Di PietroLuke A Henderson

Abstract

Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder that typically occurs in the limbs, usually the upper limb. CRPS usually develops from a peripheral event but its maintenance relies on changes within the central nervous system. While functional abnormalities in the thalamus and primary somatosensory cortex (S1) of the brain are some of the most consistently reported brain findings in CRPS, the mechanisms are yet to be explored in full, not least of all how these two regions interact and how they might relate to clinical deficits, such as the commonly reported poor tactile acuity in this condition. This study recruited 15 upper-limb CRPS subjects and 30 healthy controls and used functional magnetic resonance imaging (fMRI) to investigate infra-slow oscillations (ISOs) in critical pain regions of the brain in CRPS. As hypothesised, we found CRPS was associated with increases in resting signal intensity ISOs (0.03-0.06 Hz) in the thalamus contralateral to the painful limb in CRPS subjects. Interestingly, there was no such difference between groups in S1, however CRPS subjects displayed stronger thalamo-S1 functional connectivity than controls, and this was related to pain. As predicted, CRPS subjects di...Continue Reading

References

Dec 5, 1998·Journal of Orthopaedic Trauma·J C MacDermidJ H Roth
Oct 12, 1999·Journal of Pain and Symptom Management·B S Galer, M Jensen
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·B PlegerM Tegenthoff
Mar 11, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Vincenzo CrunelliStephen R Williams
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·S VanhataloK Kaila
Apr 28, 2004·NeuroImage·Paul M MaceyRonald M Harper
Aug 7, 2004·Brain Research. Brain Research Reviews·Didier Pinault
Mar 24, 2005·Progress in Neurobiology·Pablo Fuentealba, Mircea Steriade
Aug 24, 2005·Nature Medicine·Guo-Feng TianMaiken Nedergaard
Sep 15, 2005·Neurology·G Lorimer Moseley
Sep 27, 2005·Brain : a Journal of Neurology·Johannes SarntheinDaniel Jeanmonod
Sep 29, 2006·Glia·Eliana Scemes, Christian Giaume
Apr 25, 2007·European Journal of Pain : EJP·Christian Maihöfner, Roberto DeCol
Jul 6, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·R Norman HardenPeter R Wilson
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·D MantiniM Corbetta
Sep 13, 2008·Brain, Behavior, and Immunity·Luis Del ValleGuillermo Alexander
Sep 29, 2009·NeuroImage·Xi-Nian ZuoMichael P Milham
Oct 30, 2009·Pain Practice : the Official Journal of World Institute of Pain·Era VermaniAndrew Weeks
Apr 17, 2010·Pain·Edward G Jones
Jun 26, 2010·Frontiers in Systems Neuroscience·Yan Chao-Gan, Zang Yu-Feng
Feb 19, 2011·Journal of Neural Transmission·Monique A van RijnJacobus J van Hilten
Jun 21, 2011·Lancet Neurology·Johan MarinusJacobus J van Hilten
Aug 10, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuqiang ShiShao-Jun Tang
Apr 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luke A HendersonSylvia M Gustin
Jun 4, 2013·The Journal of Pain : Official Journal of the American Pain Society·Flavia Di PietroTasha R Stanton
Nov 26, 2013·The Journal of Pain : Official Journal of the American Pain Society·G Lorimer MoseleyJohan Marinus
Jul 2, 2014·The Journal of Pain : Official Journal of the American Pain Society·Mark J CatleyG Lorimer Moseley
Jan 23, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zeynab AlshelhLuke A Henderson
Dec 13, 2017·Neural Plasticity·Stefanie HebaTobias Schmidt-Wilcke
Jan 18, 2018·Human Brain Mapping·Flavia Di PietroLuke A Henderson
Oct 20, 2018·Nature Communications·Tara DeemyadNelson Spruston
Aug 27, 2019·Journal of Pain Research·Zeynab AlshelhLuke A Henderson

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Citations

Jun 7, 2021·Neuroscience and Biobehavioral Reviews·Anne Margarette S MaalloScott A Holmes
Jul 28, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Siyi YuJie Yang
Jan 14, 2022·The Journal of Headache and Pain·Noemi Meylakh, Luke A Henderson

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Software Mentioned

SPM12
MATLAB
SPM Data Processing Assistant for Resting State fMRI ( DPARSF )
Dynamic Retrospective Filtering ( DRIFTER )
SPSS Statistics
DPARSF

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