Altered resting state connectivity of the default mode network in alexithymia.

Social Cognitive and Affective Neuroscience
Edith Jantine LiemburgAndré Aleman

Abstract

Alexithymia is a trait characterized by a diminished capacity to describe and distinguish emotions and to fantasize; it is associated with reduced introspection and problems in emotion processing. The default mode network (DMN) is a network of brain areas that is normally active during rest and involved in emotion processing and self-referential mental activity, including introspection. We hypothesized that connectivity of the DMN might be altered in alexithymia. Twenty alexithymic and 18 non-alexithymic healthy volunteers underwent a resting state fMRI scan. Independent component analysis was used to identify the DMN. Differences in connectivity strength were compared between groups. Within the DMN, alexithymic participants showed lower connectivity within areas of the DMN (medial frontal and temporal areas) as compared to non-alexithymic participants. In contrast, connectivity in the high-alexithymic participants was higher for the sensorimotor cortex, occipital areas and right lateral frontal cortex than in the low-alexithymic participants. These results suggest a diminished connectivity within the DMN of alexithymic participants, in brain areas that may also be involved in emotional awareness and self-referential processing...Continue Reading

References

Jun 1, 1988·Journal of Personality and Social Psychology·D WatsonA Tellegen
Nov 11, 1994·Science·P T Fox, J L Lancaster
Nov 5, 1997·Biological Psychiatry·R D LaneA W Kaszniak
Apr 1, 2000·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·G J Taylor
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Oct 5, 2001·Nature Reviews. Neuroscience·D A GusnardM E Raichle
Dec 24, 2002·Journal of Cognitive Neuroscience·Kevin N OchsnerJohn D E Gabrieli
May 24, 2003·Brain : a Journal of Neurology·Michiko KanoKazuhiko Yanai
Oct 2, 2003·Nature Medicine·Paroma Basu
Nov 20, 2003·Annals of the New York Academy of Sciences·Antonio Damasio
Mar 24, 2005·NeuroImage·Arnaud D'ArgembeauEric Salmon
Apr 13, 2005·Head & Neck·Raul PelliniGiuseppe Spriano
Jun 7, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Sylvie Berthoz, Elisabeth L Hill
Jun 28, 2005·NeuroImage·Vincent G van de VenDavid E J Linden
Oct 29, 2005·The Journal of Comparative Neurology·Marcus E Raichle, Debra A Gusnard
Nov 8, 2005·Trends in Cognitive Sciences·André Aleman
Feb 3, 2006·International Review of Psychiatry·Elisabeth Waller, Carl Eduard Scheidt
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·J S DamoiseauxC F Beckmann
Dec 6, 2006·Comprehensive Psychiatry·Mascha van 't WoutRené S Kahn
Feb 28, 2007·Journal of Psychosomatic Research·Sylvie BerthozMark G Haviland
Mar 3, 2007·The American Journal of Psychiatry·Abigail G GarrityVince D Calhoun
May 10, 2007·Journal of Cognitive Neuroscience·Sang Hee Kim, Stephan Hamann
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Sep 25, 2007·Biological Psychiatry·Philippe R GoldinJames J Gross
Jan 5, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Hasse KarlssonHanna Stenman
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
May 9, 2008·Neuroreport·Robyn L BluhmPeter Williamson
Jul 18, 2008·Social Neuroscience·Giorgia SilaniUta Frith

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Citations

Jul 16, 2013·Psychiatry Research·Yunlong DengQiuping Tang
Jan 23, 2016·Journal of Affective Disorders·Nerissa S P HoTatia M C Lee
Sep 6, 2015·Social Cognitive and Affective Neuroscience·L ColicM Walter
Jun 23, 2015·Human Brain Mapping·Katharina Sophia Goerlich-DobreClaus Lamm
Jun 25, 2013·NeuroImage·Hikaru TakeuchiRyuta Kawashima
Oct 27, 2015·Social Cognitive and Affective Neuroscience·Yangmei LuoXiting Huang
Apr 28, 2016·Scandinavian Journal of Psychology·Stella G Giakoumaki
Nov 16, 2016·Scientific Reports·Claudio ImperatoriBenedetto Farina
Aug 10, 2017·Yonsei Medical Journal·Seung Jun KimJi Woong Kim
May 17, 2017·Diabetology & Metabolic Syndrome·Maria Cristina de Oliveira Regina, Marcos Antonio Tambascia
Jun 9, 2020·Frontiers in Psychology·Maria Serena PanasitiCristiano Violani
Aug 15, 2020·Frontiers in Psychology·Sarah N RigbyBrenda M Stoesz
Feb 13, 2019·Psychological Medicine·Nambeom KimSeog Ju Kim
Oct 22, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I A LapinA A Mitrofanov
Aug 21, 2019·Trends in Cognitive Sciences·Ajay B Satpute, Kristen A Lindquist
Jul 14, 2021·NeuroImage·Julian GaviriaPatrik Vuilleumier
Nov 13, 2021·The European Journal of Neuroscience·Yuri TerasawaYoshiya Moriguchi

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