Altered resting-state hippocampal and caudate functional networks in patients with obstructive sleep apnea.

Brain and Behavior
Xiaopeng SongRajesh Kumar

Abstract

Brain structural injury and metabolic deficits in the hippocampus and caudate nuclei may contribute to cognitive and emotional deficits found in obstructive sleep apnea (OSA) patients. If such contributions exist, resting-state interactions of these subcortical sites with cortical areas mediating affective symptoms and cognition should be disturbed. Our aim was to examine resting-state functional connectivity (FC) of the hippocampus and caudate to other brain areas in OSA relative to control subjects, and to relate these changes to mood and neuropsychological scores. We acquired resting-state functional magnetic resonance imaging (fMRI) data from 70 OSA and 89 healthy controls using a 3.0-Tesla magnetic resonance imaging scanner, and assessed psychological and behavioral functions, as well as sleep issues. After standard fMRI data preprocessing, FC maps were generated for bilateral hippocampi and caudate nuclei, and compared between groups (ANCOVA; covariates, age and gender). Obstructive sleep apnea subjects showed significantly higher levels of anxiety and depressive symptoms over healthy controls. In OSA subjects, the hippocampus showed disrupted FC with the thalamus, para-hippocampal gyrus, medial and superior temporal gyru...Continue Reading

References

Dec 1, 1979·Annals of Neurology·L R Squire, R Y Moore
Jun 1, 1996·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·S M OppenheimerW M Martin
Apr 17, 2001·The Behavioral and Brain Sciences·J P Aggleton, M W Brown
Aug 27, 2002·Neuron·Neil BurgessJohn O'Keefe
Jan 7, 2003·Journal of Applied Physiology·Ronald M HarperFrisca L Yan-Go
Nov 1, 2003·Sleep Medicine·Mary J MorrellDouglas R Corfield
Nov 12, 2003·Experimental Brain Research·Giacomo Rizzolatti, Massimo Matelli
Dec 13, 2005·Sleep·Amir SharafkhanehMax Hirshkowitz
Jan 20, 2007·Science·Malia F MasonC Neil Macrae
Mar 21, 2007·Sleep Medicine·Ellen T Kahn-GreeneWilliam D S Killgore
Aug 25, 2007·Annual Review of Clinical Psychology·Andrew Mathews, Colin MacLeod
Mar 29, 2008·The European Journal of Neuroscience·Attila NagyGyörgy Benedek
Oct 2, 2008·Depression and Anxiety·Rajesh KumarRonald M Harper
Nov 26, 2008·Neuroscience and Biobehavioral Reviews·Monique Ernst, Julie L Fudge
Jul 15, 2009·Sleep Medicine Reviews·Melanie HarrisRonald R Grunstein
Jun 1, 2008·Expert Review of Respiratory Medicine·Won LeeBabak Mokhlesi
Mar 3, 2010·Annual Review of Clinical Psychology·Ian H Gotlib, Jutta Joormann
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Jun 17, 2010·The European Journal of Neuroscience·John P AggletonJonathan T Erichsen
Jan 25, 2011·Neuropsychologia·Giovanni Augusto CarlesimoCarlo Caltagirone
May 31, 2011·Journal of the American Academy of Child and Adolescent Psychiatry·Mujeeb U ShadUma Rao
Feb 3, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Alimohamad AsghariMohammad Farhadi
Mar 10, 2012·Journal of Molecular Neuroscience : MN·C M R FrancoJ R M Oliveira
Jun 5, 2012·Frontiers in Neurology·Emilia Sforza, Frédéric Roche
Jun 21, 2012·Journal of Neuroscience Research·Rajesh KumarRonald M Harper
Jun 21, 2013·Nature Reviews. Neuroscience·Dan W Grupe, Jack B Nitschke
Sep 14, 2013·Current Biology : CB·Ted AbelMatthew P Walker
Nov 7, 2013·PloS One·Paul M MaceyRonald M Harper
Feb 7, 2014·Annual Review of Clinical Psychology·Andrea N Goldstein, Matthew P Walker
Feb 8, 2014·Annals of the New York Academy of Sciences·Jessica R Andrews-HannaR Nathan Spreng
May 20, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Isaac AlmendrosDavid Gozal
Aug 26, 2014·Current Behavioral Neuroscience Reports·Scott A LangeneckerAlessandra M Passarotti

❮ Previous
Next ❯

Citations

Jul 31, 2020·The Journal of Clinical Investigation·Nanduri R PrabhakarJayasri Nanduri
Aug 23, 2018·Frontiers in Behavioral Neuroscience·Bryan D DevanRobert J McDonald
Jan 12, 2019·Frontiers in Surgery·Haralampos Gouveris, Danny J Eckert

❮ Previous
Next ❯

Software Mentioned

DPARSFA
SPM12

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.