Altered serum glyceraldehyde-derived advanced glycation end product (AGE) and soluble AGE receptor levels indicate carbonyl stress in patients with schizophrenia

Neuroscience Letters
Mayu TakedaHeii Arai

Abstract

Recent cross-sectional and longitudinal studies indicate that measurements of peripheral blood carbonyl stress markers such as the advanced glycation end product (AGE) pentosidine and the reactive carbonyl-detoxifying B6 vitamin pyridoxal could be used as therapeutic biological markers in subpopulations of schizophrenia patients. Glyceraldehyde-derived AGEs (Glycer-AGE) have strong neurotoxicity, and soluble receptors for AGEs (sRAGE) may ameliorate the effects of AGEs. In the present study, we measured Glycer-AGEs and sRAGE levels to determine their potential as diagnostic, therapeutic, or clinical biological markers in patients with schizophrenia. After enrollment of 61 admitted Japanese patients with acute schizophrenia and 39 healthy volunteers, 54 patients were followed up from the acute stage to remission. Serum biomarkers were measured in blood samples taken before breakfast using competitive enzyme-linked immunosorbent assays, and Glycer-AGEs were significantly higher and sRAGE levels were significantly lower in patients with acute schizophrenia than in healthy controls. Glycer-AGEs/sRAGE ratios were also higher in schizophrenia patients and were stable during the clinical course. Furthermore, discriminant analyses conf...Continue Reading

References

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Jun 14, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tohru OhnumaHeii Arai
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Hideyuki HyogoSusumu Tazuma
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Citations

Jul 16, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Toru NakamuraHeii Arai
Sep 20, 2016·Biochemical and Biophysical Research Communications·Mitsuhiro MiyashitaMakoto Arai
Mar 26, 2016·World Journal of Psychiatry·Chi-Yu LaiBrian Dean
Feb 1, 2019·International Journal of Methods in Psychiatric Research·Eriko TaniHeii Arai
Jul 15, 2020·International Journal of Molecular Sciences·Akiko Sakasai-SakaiMasayoshi Takeuchi
Mar 1, 2019·Nutrients·Akiko Sakasai-SakaiMasayoshi Takeuchi
Mar 21, 2021·Pflügers Archiv : European journal of physiology·Halyna Semchyshyn

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