PMID: 9527274Apr 4, 1998Paper

Altered serum levels of insulin-like growth-factor binding proteins in breast cancer patients

Annals of Surgical Oncology
E H NgK O Lee

Abstract

Insulin-like growth factor 1 (IGF-1) has mitogenic properties for breast cancer cell lines and has been proposed to be an important factor in breast carcinogenesis. We hypothesized that differences in IGF-1 or its binding proteins might increase susceptibility to breast cancer. This case-control study was designed to investigate whether patients with breast cancer have altered levels of either IGF-1 or its intermediary modulatory proteins, the IGF binding proteins (BP). Serum was collected from 90 patients (63 with breast cancer and 27 with benign breast disease) after an overnight fast and before surgery. IGF-1, BP1, and BP3 levels were determined by immunoradiometric assays. In a subset of 66 patients, Western ligand blots were also performed for a semiquantitative measurement of functioning BP levels. A forward stepwise logistic regression model to adjust for other confounding variables (age, menopausal status, parity, age at menarche, use of oral contraceptives, history of breast biopsy, family history of breast cancer, hormone replacement therapy, and body-mass index) was used in the multivariate analysis. Serum IGF-1 levels were similar in cases and controls. However, levels of BP3 (p < 0.001), BP4 (p < 0.01), and BP1 (p ...Continue Reading

References

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Citations

Jun 13, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·B A Stoll
Aug 2, 2002·Breast Cancer Research and Treatment·Pamela J GoodwinNicky Hood
Nov 10, 2000·International Journal of Cancer. Journal International Du Cancer·P TonioloA Zeleniuch-Jacquotte
Jan 6, 2009·Archives of Gynecology and Obstetrics·Ilknur Inegol GumusNilgun Ozturk Turhan
Jul 4, 2002·Annals of the New York Academy of Sciences·Rudolf Kaaks, Annekatrin Lukanova
Jun 29, 2004·International Journal of Cancer. Journal International Du Cancer·Runhua ShiJonathan Glass
Nov 17, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kerri M Winters-StoneNathan F Dieckmann
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christian F SingerMartin Schreiber
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B A Stoll
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Svein Inge Helle

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