Altered Serum Levels of Matrix Metalloproteinase-2, -9 in Response to Electroconvulsive Therapy for Mood Disorders

The International Journal of Neuropsychopharmacology
Chiyo ShibasakiShigeto Yamawaki

Abstract

Inflammatory processes could underlie mood disorders. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMP) are inflammation-related molecules. The current study sought an association between mood disorders and systemic levels of MMPs and TIMPs. Serum was obtained from patients with mood disorders (n=21) and patients with schizophrenia (n=13) scheduled to undergo electroconvulsive therapy. Serum was also obtained from healthy controls (n=40). Clinical symptoms were assessed by the Hamilton Rating Score for Depression and the Brief Psychiatric Rating Scale. Serum levels of MMPs and TIMPs were quantified by ELISA. The serum levels of MMP-2 in mood disorder patients, but not in schizophrenia patients, prior to the first electroconvulsive therapy session (baseline) was significantly lower than that of healthy controls. At baseline, levels of MMP-9 and TIMP-2, -1 were not different between patients with mood disorder and schizophrenia and healthy controls. After a course of electroconvulsive therapy, MMP-2 levels were significantly increased in mood disorder patients, but MMP-9 levels were significantly decreased in both mood disorder and schizophrenia patients. In mood disorder patients, there was a significant nega...Continue Reading

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Citations

Jul 15, 2016·International Journal of Molecular Sciences·Dominik StrzeleckiAdam Wysokiński
Jul 20, 2016·Journal of Affective Disorders·Kinga BobińskaPiotr Gałecki
Sep 8, 2016·Analytical and Bioanalytical Chemistry·Manveen K Sethi, Joseph Zaia
Feb 5, 2019·The International Journal of Neuropsychopharmacology·Kei ItagakiShigeto Yamawaki
May 17, 2019·International Journal of Psychiatry in Clinical Practice·Qing-Rong XiaYa-Yun Xu
Jun 7, 2019·Cellular and Molecular Life Sciences : CMLS·Anna BerounLeszek Kaczmarek
Jul 17, 2020·The International Journal of Neuropsychopharmacology·Wataru OmoriMinoru Takebayashi
Sep 18, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hikaru ItoHidenori Aizawa
Jul 21, 2020·Neuroscience and Biobehavioral Reviews·Sabine SpijkerDanai Riga
Nov 18, 2020·Brain Research Bulletin·Mingyue WangDongdong Qin
Apr 21, 2021·The European Journal of Neuroscience·Ellen DoneyCaroline Menard

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Methods Mentioned

BETA
pharmacotherapy
X-ray
ELISA

Software Mentioned

SPSS

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