Altered sodium-calcium exchange in afferent arterioles of the spontaneously hypertensive rat

Kidney International
L D NelsonP D Bell

Abstract

Studies were performed to determine if there is a derangement in Na-Ca exchange activity in afferent (AA) and efferent (EA) arterioles from 3- and 9-week-old spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. Cytosolic calcium concentration ([Ca2+]i) was assessed using microscope-based photometry in fura-2 loaded arterioles bathed in a Ringer's solution. Baseline [Ca2+]i was similar in the AA of 3- and 9-week-old WKY and SHR. In AA from 3-week-old rats, [Ca2+]i increased by 89 +/- 15 nM in WKY and by 73 +/- 13 nM in SHR during decreases in bath sodium concentration ([Na+]e) from 150 to 2 mM (Na+ replaced with n-methyl-D-glucamine). In 9-week-old hypertensive SHR (SBP = 150 mm Hg), increases in [Ca2+]i were attenuated (24 +/- 3 nM) relative to 3-week-old WKY and SHR, and 9-week-old WKY (90 +/- 9 nM; P < 0.05). Likewise, the rate of removal of Ca2+ in the continued presence of 2 mM Nae (Ca2+ sequestration and/or extrusion) was markedly reduced in AA of 9-week-old SHR (-0.15 +/- 0.03 nM/second) versus 3-week-old SHR (-0.72 +/- 0.12 nM/second) and 3- and 9-week-old WKY (-0.49 +/- 0.10 and -0.67 +/- 0.14 nM/second). In other experiments, AAs were preincubated in 1 mM ouabain to increase intracellular [Na+]. This maneuver ...Continue Reading

References

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Citations

Sep 29, 1999·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S E AndersonP M Cala
Feb 26, 2000·Acta Physiologica Scandinavica·P D BellM T Unlap
Feb 20, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bharathy Ponnuchamy, Raouf A Khalil
May 23, 2008·American Journal of Physiology. Renal Physiology·Xuemei WangRodger Loutzenhiser
Mar 24, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshihiro KokuboToshiyuki Miyata
Apr 21, 2007·Annals of the New York Academy of Sciences·Yun-Min Zheng, Yong-Xiao Wang
Nov 21, 2014·Clinical and Experimental Nephrology·Midori Sasaki YatabeTsuyoshi Watanabe
Jul 30, 2003·Hypertension·M Tino UnlapP Darwin Bell
Dec 16, 2004·American Journal of Physiology. Renal Physiology·Frank H HansenBjarne M Iversen
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Jan 3, 2001·American Journal of Physiology. Renal Physiology·F SchwedaA Kurtz
Jul 18, 2001·American Journal of Physiology. Renal Physiology·M Salomonsson, W J Arendshorst
Apr 13, 1999·The American Journal of Physiology·N A MashburnP D Bell
Apr 13, 1999·The American Journal of Physiology·L D NelsonP D Bell
Oct 12, 1999·The American Journal of Physiology·S K Fellner, W J Arendshorst

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