Altered source memory retrieval is associated with pathological doubt in obsessive-compulsive disorder

Behavioural Brain Research
Christy A OlsonCary R Savage

Abstract

Individuals with obsessive-compulsive disorder (OCD) often complain of doubt related to memory. As neuropsychological research has demonstrated that individuals with OCD tend to focus on details and miss the larger context, the construct of source (contextual) memory may be particularly relevant to memory complaints in OCD. Memory for object versus contextual information relies on partially distinct regions within the prefrontal cortex, parietal and medial temporal lobe, and may be differentially impacted by OCD. In the present study, we sought to test the hypothesis that individuals with OCD exhibit impaired source memory retrieval using a novel memory paradigm - The Memory for Rooms Test (MFRT) - a four-room memory task in which participants walk through four rooms and attempt to encode and remember objects. Demographically matched individuals with OCD and healthy controls studied objects in the context of four rooms, and then completed a memory retrieval test while undergoing functional magnetic resonance imaging (fMRI). While no differences were observed in source memory accuracy, individuals with OCD exhibited greater task related activation in the posterior cingulate cortex (PCC) relative to healthy controls during correc...Continue Reading

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May 24, 2019·Psychological Medicine·Arun RavindranNorman Farb
Mar 10, 2020·World Journal of Psychiatry·Layla LavalléMarine Mondino
Jan 9, 2021·Molecular Psychiatry·Elizabeth ShephardEuripedes C Miguel

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