Altered spontaneous brain activity in patients with acute spinal cord injury revealed by resting-state functional MRI

PloS One
Ling ZhuFuchun Lin

Abstract

Previous neuroimaging studies have provided evidence of structural and functional reorganization of brain in patients with chronic spinal cord injury (SCI). However, it remains unknown whether the spontaneous brain activity changes in acute SCI. In this study, we investigated intrinsic brain activity in acute SCI patients using a regional homogeneity (ReHo) analysis based on resting-state functional magnetic resonance imaging. A total of 15 patients with acute SCI and 16 healthy controls participated in the study. The ReHo value was used to evaluate spontaneous brain activity, and voxel-wise comparisons of ReHo were performed to identify brain regions with altered spontaneous brain activity between groups. We also assessed the associations between ReHo and the clinical scores in brain regions showing changed spontaneous brain activity. Compared with the controls, the acute SCI patients showed decreased ReHo in the bilateral primary motor cortex/primary somatosensory cortex, bilateral supplementary motor area/dorsal lateral prefrontal cortex, right inferior frontal gyrus, bilateral dorsal anterior cingulate cortex and bilateral caudate; and increased ReHo in bilateral precuneus, the left inferior parietal lobe, the left brainste...Continue Reading

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Citations

Nov 23, 2017·Frontiers in Human Neuroscience·Alkinoos AthanasiouPanagiotis D Bamidis

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Methods Mentioned

BETA
SMA

Software Mentioned

Rs
Statistical Product and Service Solutions Statistics
SPSS Statistics
AlphaSim

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